Obsessive-compulsive disorder, 5-HTTLPR polymorphism and treatment response

D. Di Bella, S. Erzegovesi, M. C. Cavallini, L. Bellodi

Research output: Contribution to journalArticle

Abstract

Recently, a role for a functional polymorphism within the promoter region of the serotonin transporter gene (5-HTTLPR) in conferring susceptibility to Obsessive Compulsive Disorder (OCD) has been suggested. The aim of this study was to test the hypothesis that allelic variation of the 5-HTTLPR could be associated with OCD susceptibility or influence the drug response in OCD. One hundred and eighty-one OCD patients were recruited; 92 patients underwent a standardized treatment with fluvoxamine. No significant differences in allele/genotype distribution of the 5-HTTLPR were found between 191 controls and OCD. No differences in fluvoxamine response in the three genotypes groups in OCD were found, considering Yale-Brown Obsessive Compulsive Scale (YBOCS) total scores. Nevertheless, a significant time per genotype interaction was found for the YBOCS subtotal compulsion scores. Considering patients without tic disorder co-diagnosis, a significant time per genotype, interaction for both YBOCS total scores and compulsion scores was found.

Original languageEnglish
Pages (from-to)176-181
Number of pages6
JournalPharmacogenomics Journal
Volume2
Issue number3
DOIs
Publication statusPublished - 2002

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Keywords

  • Fluvoxamine
  • Pharmacogenetics
  • Serotonin
  • Serotonin reuptake inhibitors
  • Tic disorder

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Genetics

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