Obsessive-compulsive disorder and migraine with medication-overuse headache: Research submission

Letizia Maria Cupini, Marco D. Murtas, Cinzia Costa, Maria Mancini, Paolo Eusebi, Paola Sarchielli, Paolo Calabresi

Research output: Contribution to journalArticlepeer-review


Objective. - A strong association has been demonstrated between migraine, particularly in the chronic form and with medication overuse, and either major depression or various anxiety disorders. However, there has been less systematic research on the links between migraine with medication-overuse headache (MOH) and obsessive-compulsive disorder (OCD). A drug-seeking behavior shares with OCD the compulsive quality of the behavior. We investigated the relationship between OCD and MOH in migraineurs. Methods. - A structured questionnaire was administered to subjects with: episodic migraine (EM) (n = 30), chronic migraine (CM) (n = 24), and MOH with a previous history of EM (n = 33) and 29 control subjects. Psychiatric diagnoses were made by a senior psychiatrist blinded to the diagnosis of migraine. Psychiatric assessment of OCD illness was evaluated by means of The Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results. - In the subgroup of patients with MOH, psychiatric comorbidity (anxiety and mood disorders) was prevalent compared with CM, EM, and controls (P

Original languageEnglish
Pages (from-to)1005-1013
Number of pages9
Issue number7
Publication statusPublished - Jul 2009


  • Chronic migraine
  • Episodic migraine
  • Medication-overuse headache
  • Obsessive-compulsive disorder

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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