Obsessive-compulsive spectrum and serotonin

A genetic association study

A. Rotondo, C. M. Mazzanti, A. Gemignani, C. Pfanner, S. Presta, A. Milanfranchi, M. R. Doria, C. Gonnelli, D. Goldman, L. Dell'Osso, G. B. Cassano

Research output: Contribution to journalArticle

Abstract

Dysfunction in serotonin (5-HT) neurotransmission in obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD) has been reported. Therefore, genetic variants of serotonergic genes could account for the genetic liability for OCD and/or OCPD. We analyzed an insertion/deletion polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) and a G to A polymorphism at base position -1438 of the 5-HT2A receptor gene (5-HT2A[-14381G/A). We studied the association of 5-HTTLPR and 5-HT2A[-1438]G/A with OCD, OCPD, and associated features of OCD and OCPD, such as impulsive-aggressive behavior and personality dimensions. One hundred fifty unrelated OCD subjects, 78 patients with OCPD and 140 healthy controls participated in the study. Aggressive behavior was evaluated by the Buss & Durkee Hostility Inventory (BDHI). Personality dimensions were evaluated by the Tridimensional Personality Questionnaire (TPQ). 5-HTTLPR and 5-HT2A[-1438]G/A were genotyped as described elsewhere. No significant differences in genotype or allele frequencies of both 5-HTTLPR and 5-HT2A[-1438]G/A were observed among OCD, OCPD and controls. No significant association was observed between BDHI scores and both 5-HTTLPR and 5-HT2AI-14381G/A genotypes in OCD or OCPD. 5-HTTLPR SS genotype was significantly associated with harm avoidance scores of the TPQ in both OCD and OCPD. The association of 5-HTTLPR with harm avoidance in both OCD and OCPD reflects the importance of defining psychopathological features associated with major psychiatric disorders.

Original languageEnglish
Pages (from-to)525
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume96
Issue number4
Publication statusPublished - Aug 7 2000

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Compulsive Personality Disorder
Obsessive-Compulsive Disorder
Genetic Association Studies
Serotonin
Personality
Genotype

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Rotondo, A., Mazzanti, C. M., Gemignani, A., Pfanner, C., Presta, S., Milanfranchi, A., ... Cassano, G. B. (2000). Obsessive-compulsive spectrum and serotonin: A genetic association study. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(4), 525.

Obsessive-compulsive spectrum and serotonin : A genetic association study. / Rotondo, A.; Mazzanti, C. M.; Gemignani, A.; Pfanner, C.; Presta, S.; Milanfranchi, A.; Doria, M. R.; Gonnelli, C.; Goldman, D.; Dell'Osso, L.; Cassano, G. B.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 96, No. 4, 07.08.2000, p. 525.

Research output: Contribution to journalArticle

Rotondo, A, Mazzanti, CM, Gemignani, A, Pfanner, C, Presta, S, Milanfranchi, A, Doria, MR, Gonnelli, C, Goldman, D, Dell'Osso, L & Cassano, GB 2000, 'Obsessive-compulsive spectrum and serotonin: A genetic association study', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 96, no. 4, pp. 525.
Rotondo, A. ; Mazzanti, C. M. ; Gemignani, A. ; Pfanner, C. ; Presta, S. ; Milanfranchi, A. ; Doria, M. R. ; Gonnelli, C. ; Goldman, D. ; Dell'Osso, L. ; Cassano, G. B. / Obsessive-compulsive spectrum and serotonin : A genetic association study. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2000 ; Vol. 96, No. 4. pp. 525.
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