TY - JOUR
T1 - Obsessive-compulsive spectrum and serotonin
T2 - A genetic association study
AU - Rotondo, A.
AU - Mazzanti, C. M.
AU - Gemignani, A.
AU - Pfanner, C.
AU - Presta, S.
AU - Milanfranchi, A.
AU - Doria, M. R.
AU - Gonnelli, C.
AU - Goldman, D.
AU - Dell'Osso, L.
AU - Cassano, G. B.
PY - 2000/8/7
Y1 - 2000/8/7
N2 - Dysfunction in serotonin (5-HT) neurotransmission in obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD) has been reported. Therefore, genetic variants of serotonergic genes could account for the genetic liability for OCD and/or OCPD. We analyzed an insertion/deletion polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) and a G to A polymorphism at base position -1438 of the 5-HT2A receptor gene (5-HT2A[-14381G/A). We studied the association of 5-HTTLPR and 5-HT2A[-1438]G/A with OCD, OCPD, and associated features of OCD and OCPD, such as impulsive-aggressive behavior and personality dimensions. One hundred fifty unrelated OCD subjects, 78 patients with OCPD and 140 healthy controls participated in the study. Aggressive behavior was evaluated by the Buss & Durkee Hostility Inventory (BDHI). Personality dimensions were evaluated by the Tridimensional Personality Questionnaire (TPQ). 5-HTTLPR and 5-HT2A[-1438]G/A were genotyped as described elsewhere. No significant differences in genotype or allele frequencies of both 5-HTTLPR and 5-HT2A[-1438]G/A were observed among OCD, OCPD and controls. No significant association was observed between BDHI scores and both 5-HTTLPR and 5-HT2AI-14381G/A genotypes in OCD or OCPD. 5-HTTLPR SS genotype was significantly associated with harm avoidance scores of the TPQ in both OCD and OCPD. The association of 5-HTTLPR with harm avoidance in both OCD and OCPD reflects the importance of defining psychopathological features associated with major psychiatric disorders.
AB - Dysfunction in serotonin (5-HT) neurotransmission in obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD) has been reported. Therefore, genetic variants of serotonergic genes could account for the genetic liability for OCD and/or OCPD. We analyzed an insertion/deletion polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) and a G to A polymorphism at base position -1438 of the 5-HT2A receptor gene (5-HT2A[-14381G/A). We studied the association of 5-HTTLPR and 5-HT2A[-1438]G/A with OCD, OCPD, and associated features of OCD and OCPD, such as impulsive-aggressive behavior and personality dimensions. One hundred fifty unrelated OCD subjects, 78 patients with OCPD and 140 healthy controls participated in the study. Aggressive behavior was evaluated by the Buss & Durkee Hostility Inventory (BDHI). Personality dimensions were evaluated by the Tridimensional Personality Questionnaire (TPQ). 5-HTTLPR and 5-HT2A[-1438]G/A were genotyped as described elsewhere. No significant differences in genotype or allele frequencies of both 5-HTTLPR and 5-HT2A[-1438]G/A were observed among OCD, OCPD and controls. No significant association was observed between BDHI scores and both 5-HTTLPR and 5-HT2AI-14381G/A genotypes in OCD or OCPD. 5-HTTLPR SS genotype was significantly associated with harm avoidance scores of the TPQ in both OCD and OCPD. The association of 5-HTTLPR with harm avoidance in both OCD and OCPD reflects the importance of defining psychopathological features associated with major psychiatric disorders.
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M3 - Article
AN - SCOPUS:33749088623
VL - 96
SP - 525
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 4
ER -