Abstract
Dysfunction in serotonin (5-HT) neurotransmission in obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD) has been reported. Therefore, genetic variants of serotonergic genes could account for the genetic liability for OCD and/or OCPD. We analyzed an insertion/deletion polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) and a G to A polymorphism at base position -1438 of the 5-HT2A receptor gene (5-HT2A[-14381G/A). We studied the association of 5-HTTLPR and 5-HT2A[-1438]G/A with OCD, OCPD, and associated features of OCD and OCPD, such as impulsive-aggressive behavior and personality dimensions. One hundred fifty unrelated OCD subjects, 78 patients with OCPD and 140 healthy controls participated in the study. Aggressive behavior was evaluated by the Buss & Durkee Hostility Inventory (BDHI). Personality dimensions were evaluated by the Tridimensional Personality Questionnaire (TPQ). 5-HTTLPR and 5-HT2A[-1438]G/A were genotyped as described elsewhere. No significant differences in genotype or allele frequencies of both 5-HTTLPR and 5-HT2A[-1438]G/A were observed among OCD, OCPD and controls. No significant association was observed between BDHI scores and both 5-HTTLPR and 5-HT2AI-14381G/A genotypes in OCD or OCPD. 5-HTTLPR SS genotype was significantly associated with harm avoidance scores of the TPQ in both OCD and OCPD. The association of 5-HTTLPR with harm avoidance in both OCD and OCPD reflects the importance of defining psychopathological features associated with major psychiatric disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 525 |
| Number of pages | 1 |
| Journal | American Journal of Medical Genetics - Neuropsychiatric Genetics |
| Volume | 96 |
| Issue number | 4 |
| Publication status | Published - Aug 7 2000 |
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ASJC Scopus subject areas
- Genetics(clinical)
- Neuropsychology and Physiological Psychology
- Neuroscience(all)
Cite this
Obsessive-compulsive spectrum and serotonin : A genetic association study. / Rotondo, A.; Mazzanti, C. M.; Gemignani, A.; Pfanner, C.; Presta, S.; Milanfranchi, A.; Doria, M. R.; Gonnelli, C.; Goldman, D.; Dell'Osso, L.; Cassano, G. B.
In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 96, No. 4, 07.08.2000, p. 525.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obsessive-compulsive spectrum and serotonin
T2 - A genetic association study
AU - Rotondo, A.
AU - Mazzanti, C. M.
AU - Gemignani, A.
AU - Pfanner, C.
AU - Presta, S.
AU - Milanfranchi, A.
AU - Doria, M. R.
AU - Gonnelli, C.
AU - Goldman, D.
AU - Dell'Osso, L.
AU - Cassano, G. B.
PY - 2000/8/7
Y1 - 2000/8/7
N2 - Dysfunction in serotonin (5-HT) neurotransmission in obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD) has been reported. Therefore, genetic variants of serotonergic genes could account for the genetic liability for OCD and/or OCPD. We analyzed an insertion/deletion polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) and a G to A polymorphism at base position -1438 of the 5-HT2A receptor gene (5-HT2A[-14381G/A). We studied the association of 5-HTTLPR and 5-HT2A[-1438]G/A with OCD, OCPD, and associated features of OCD and OCPD, such as impulsive-aggressive behavior and personality dimensions. One hundred fifty unrelated OCD subjects, 78 patients with OCPD and 140 healthy controls participated in the study. Aggressive behavior was evaluated by the Buss & Durkee Hostility Inventory (BDHI). Personality dimensions were evaluated by the Tridimensional Personality Questionnaire (TPQ). 5-HTTLPR and 5-HT2A[-1438]G/A were genotyped as described elsewhere. No significant differences in genotype or allele frequencies of both 5-HTTLPR and 5-HT2A[-1438]G/A were observed among OCD, OCPD and controls. No significant association was observed between BDHI scores and both 5-HTTLPR and 5-HT2AI-14381G/A genotypes in OCD or OCPD. 5-HTTLPR SS genotype was significantly associated with harm avoidance scores of the TPQ in both OCD and OCPD. The association of 5-HTTLPR with harm avoidance in both OCD and OCPD reflects the importance of defining psychopathological features associated with major psychiatric disorders.
AB - Dysfunction in serotonin (5-HT) neurotransmission in obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD) has been reported. Therefore, genetic variants of serotonergic genes could account for the genetic liability for OCD and/or OCPD. We analyzed an insertion/deletion polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) and a G to A polymorphism at base position -1438 of the 5-HT2A receptor gene (5-HT2A[-14381G/A). We studied the association of 5-HTTLPR and 5-HT2A[-1438]G/A with OCD, OCPD, and associated features of OCD and OCPD, such as impulsive-aggressive behavior and personality dimensions. One hundred fifty unrelated OCD subjects, 78 patients with OCPD and 140 healthy controls participated in the study. Aggressive behavior was evaluated by the Buss & Durkee Hostility Inventory (BDHI). Personality dimensions were evaluated by the Tridimensional Personality Questionnaire (TPQ). 5-HTTLPR and 5-HT2A[-1438]G/A were genotyped as described elsewhere. No significant differences in genotype or allele frequencies of both 5-HTTLPR and 5-HT2A[-1438]G/A were observed among OCD, OCPD and controls. No significant association was observed between BDHI scores and both 5-HTTLPR and 5-HT2AI-14381G/A genotypes in OCD or OCPD. 5-HTTLPR SS genotype was significantly associated with harm avoidance scores of the TPQ in both OCD and OCPD. The association of 5-HTTLPR with harm avoidance in both OCD and OCPD reflects the importance of defining psychopathological features associated with major psychiatric disorders.
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M3 - Article
VL - 96
SP - 525
JO - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 4
ER -