Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa

P Navas, A Paffoni, Giulia Intra, A González-Utor, A Clavero, MC Gonzalvo, R Díaz, R Peña, L Restelli, E Somigliana, E Papaleo, JA Castilla, P Viganò

Research output: Contribution to journalArticlepeer-review

Abstract

Pentoxifylline (PF) represents an effective tool in stimulating motility and identifying viable spermatozoa in intracytoplasmic sperm injection (ICSI) patients presenting exclusively with immotile spermatozoa. However, its use is not universally accepted for its possible detrimental effects on oocytes, embryos or newborns. To evaluate whether PF use may affect obstetrical/neo-natal outcomes, 102 patients achieving a clinical pregnancy after a PF-ICSI in four IVF units in Spain and Italy were followed up after delivery. Neo-natal malformations were classified according to the World Health Organization International Classification of Diseases (ICD-10, range Q00-Q99). Malformation rate was compared with data published by other groups regarding children conceived by conventional IVF or ICSI reporting a 5.3% and 4.4% frequency of ICD-10 codes, respectively. Of 134 clinical pregnancies, 122 babies (82 singletons and 40 twins) were registered. Among singletons, the rates of low birthweight (≤2500 g) and preterm birth (
Original languageEnglish
Pages (from-to)414-421
Number of pages8
JournalReproductive BioMedicine Online
Volume34
Issue number4
DOIs
Publication statusPublished - 2017

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