Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies

Paolo Emanuele Levi Setti, Melita Moioli, Antonella Smeraldi, Elisa Cesaratto, Francesca Menduni, Stefania Livio, Emanuela Morenghi, Pasquale Patrizio

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: The aim of this study was to provide a comprehensive follow-up of fetal and perinatal outcome and the incidence of congenital anomalies in babies born after fresh embryo transfers compared to those conceived spontaneously in infertile couples. Methods: Retrospective comparative analysis of all clinical pregnancies from fresh cleavage-stage embryo transfer cycles (IVF and ICSI) compared with infertile patients who conceived spontaneously in the same time period (control). Congenital anomalies were classified following the European Surveillance of Congenital Anomalies (EUROCAT) classification. Results: A total of 2414 assisted reproductive technology (ART) pregnancies were compared to 582 spontaneous conceptions in the control infertile group representing 2306 deliveries. No significant differences were found in pregnancy outcome between the two groups (delivery rate, abortion rate, ectopic pregnancies, medical abortions for fetal anomalies, single and twins mean gestational age, and weight at delivery). A significant difference (p <0.001) was found in the twin (21.3 vs 2.3 %) and triplet rates (2.3 vs 0 %). A total of 2351 babies were delivered in the ART group and 449 in the control group. A total of 90 babies (3.8 %) were diagnosed with a major congenital anomaly in the ART group and 15 (3.3 %) in the control group (p = ns). The overall rate of major congenital anomalies (105/2800) in ART and spontaneous pregnancies in infertile couples was significantly higher when compared to the EUROCAT 2.0 versus 3.75 % (p = 0.0002). Discussion: Babies born after ART treatments and from spontaneous conception in infertile couples had rates of congenital anomalies higher than those recorded by the EUROCAT. However, the rates of anomalies were not different within the infertile population whether conceived by ART or spontaneously. These data suggest that the diagnosis of infertility in itself is the common denominator for the increase in the rates of anomalies seen in both ART and spontaneous conceptions.

Original languageEnglish
Pages (from-to)711-717
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume33
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Assisted Reproductive Techniques
Intracytoplasmic Sperm Injections
Obstetrics
Incidence
Embryo Transfer
Pregnancy
Control Groups
Induced Abortion
Ectopic Pregnancy
Pregnancy Outcome
Infertility
Gestational Age
Weights and Measures
Population

Keywords

  • ART
  • ICSI
  • IVF
  • Neonatal anomalies
  • Pregnancy outcome

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies. / Levi Setti, Paolo Emanuele; Moioli, Melita; Smeraldi, Antonella; Cesaratto, Elisa; Menduni, Francesca; Livio, Stefania; Morenghi, Emanuela; Patrizio, Pasquale.

In: Journal of Assisted Reproduction and Genetics, Vol. 33, No. 6, 01.06.2016, p. 711-717.

Research output: Contribution to journalArticle

Levi Setti, PE, Moioli, M, Smeraldi, A, Cesaratto, E, Menduni, F, Livio, S, Morenghi, E & Patrizio, P 2016, 'Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies', Journal of Assisted Reproduction and Genetics, vol. 33, no. 6, pp. 711-717. https://doi.org/10.1007/s10815-016-0714-4
Levi Setti, Paolo Emanuele ; Moioli, Melita ; Smeraldi, Antonella ; Cesaratto, Elisa ; Menduni, Francesca ; Livio, Stefania ; Morenghi, Emanuela ; Patrizio, Pasquale. / Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies. In: Journal of Assisted Reproduction and Genetics. 2016 ; Vol. 33, No. 6. pp. 711-717.
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abstract = "Purpose: The aim of this study was to provide a comprehensive follow-up of fetal and perinatal outcome and the incidence of congenital anomalies in babies born after fresh embryo transfers compared to those conceived spontaneously in infertile couples. Methods: Retrospective comparative analysis of all clinical pregnancies from fresh cleavage-stage embryo transfer cycles (IVF and ICSI) compared with infertile patients who conceived spontaneously in the same time period (control). Congenital anomalies were classified following the European Surveillance of Congenital Anomalies (EUROCAT) classification. Results: A total of 2414 assisted reproductive technology (ART) pregnancies were compared to 582 spontaneous conceptions in the control infertile group representing 2306 deliveries. No significant differences were found in pregnancy outcome between the two groups (delivery rate, abortion rate, ectopic pregnancies, medical abortions for fetal anomalies, single and twins mean gestational age, and weight at delivery). A significant difference (p <0.001) was found in the twin (21.3 vs 2.3 {\%}) and triplet rates (2.3 vs 0 {\%}). A total of 2351 babies were delivered in the ART group and 449 in the control group. A total of 90 babies (3.8 {\%}) were diagnosed with a major congenital anomaly in the ART group and 15 (3.3 {\%}) in the control group (p = ns). The overall rate of major congenital anomalies (105/2800) in ART and spontaneous pregnancies in infertile couples was significantly higher when compared to the EUROCAT 2.0 versus 3.75 {\%} (p = 0.0002). Discussion: Babies born after ART treatments and from spontaneous conception in infertile couples had rates of congenital anomalies higher than those recorded by the EUROCAT. However, the rates of anomalies were not different within the infertile population whether conceived by ART or spontaneously. These data suggest that the diagnosis of infertility in itself is the common denominator for the increase in the rates of anomalies seen in both ART and spontaneous conceptions.",
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AU - Menduni, Francesca

AU - Livio, Stefania

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