TY - JOUR
T1 - Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity
AU - Grassi, Guido
AU - Facchini, Anna
AU - Trevano, Fosca Quarti
AU - Dell'Oro, Raffaella
AU - Arenare, Francesca
AU - Tana, Francesco
AU - Bolla, Gianbattista
AU - Monzani, Anna
AU - Robuschi, Maria
AU - Mancia, Giuseppe
PY - 2005/8
Y1 - 2005/8
N2 - No agreement exists as to the mechanisms responsible for the sympathetic hyperactivity characterizing human obesity, which has been ascribed recently to a chemoreflex stimulation brought about by obstructive sleep apnea rather than to an increase in body weight, per se. In 86 middle-age normotensive subjects classified according to body mass index, waist-to-hip ratio, and apnea/hypopnea index (overnight polysomnographic evaluation) as lean and obese subjects without or with obstructive sleep apnea, we assessed via microneurography muscle sympathetic nerve traffic. The 4 groups were matched for age, gender, and blood pressure values, the 2 obese groups with and without obstructive sleep apnea showing a similar increase in body mass index (32.4 versus 32.0 kg/m 2, respectively) and waist-to-hip ratio (0.96 versus 0.95, respectively) compared with the 2 lean groups with or without obstructive sleep apnea (body mass index 24.3 versus 23.8 kg/m2 and waist-to-hip ratio 0.77 versus 0.76, respectively; P
AB - No agreement exists as to the mechanisms responsible for the sympathetic hyperactivity characterizing human obesity, which has been ascribed recently to a chemoreflex stimulation brought about by obstructive sleep apnea rather than to an increase in body weight, per se. In 86 middle-age normotensive subjects classified according to body mass index, waist-to-hip ratio, and apnea/hypopnea index (overnight polysomnographic evaluation) as lean and obese subjects without or with obstructive sleep apnea, we assessed via microneurography muscle sympathetic nerve traffic. The 4 groups were matched for age, gender, and blood pressure values, the 2 obese groups with and without obstructive sleep apnea showing a similar increase in body mass index (32.4 versus 32.0 kg/m 2, respectively) and waist-to-hip ratio (0.96 versus 0.95, respectively) compared with the 2 lean groups with or without obstructive sleep apnea (body mass index 24.3 versus 23.8 kg/m2 and waist-to-hip ratio 0.77 versus 0.76, respectively; P
KW - Baroreflex
KW - Chemoreceptors
KW - Sleep apnea syndromes
KW - Sympathetic nervous system
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U2 - 10.1161/01.HYP.0000174243.39897.6c
DO - 10.1161/01.HYP.0000174243.39897.6c
M3 - Article
C2 - 15983234
AN - SCOPUS:23244437764
VL - 46
SP - 321
EP - 325
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -