Abstract
No agreement exists as to the mechanisms responsible for the sympathetic hyperactivity characterizing human obesity, which has been ascribed recently to a chemoreflex stimulation brought about by obstructive sleep apnea rather than to an increase in body weight, per se. In 86 middle-age normotensive subjects classified according to body mass index, waist-to-hip ratio, and apnea/hypopnea index (overnight polysomnographic evaluation) as lean and obese subjects without or with obstructive sleep apnea, we assessed via microneurography muscle sympathetic nerve traffic. The 4 groups were matched for age, gender, and blood pressure values, the 2 obese groups with and without obstructive sleep apnea showing a similar increase in body mass index (32.4 versus 32.0 kg/m 2, respectively) and waist-to-hip ratio (0.96 versus 0.95, respectively) compared with the 2 lean groups with or without obstructive sleep apnea (body mass index 24.3 versus 23.8 kg/m2 and waist-to-hip ratio 0.77 versus 0.76, respectively; P
| Original language | English |
|---|---|
| Pages (from-to) | 321-325 |
| Number of pages | 5 |
| Journal | Hypertension |
| Volume | 46 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2005 |
Fingerprint
Keywords
- Baroreflex
- Chemoreceptors
- Sleep apnea syndromes
- Sympathetic nervous system
ASJC Scopus subject areas
- Internal Medicine
Cite this
Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity. / Grassi, Guido; Facchini, Anna; Trevano, Fosca Quarti; Dell'Oro, Raffaella; Arenare, Francesca; Tana, Francesco; Bolla, Gianbattista; Monzani, Anna; Robuschi, Maria; Mancia, Giuseppe.
In: Hypertension, Vol. 46, No. 2, 08.2005, p. 321-325.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity
AU - Grassi, Guido
AU - Facchini, Anna
AU - Trevano, Fosca Quarti
AU - Dell'Oro, Raffaella
AU - Arenare, Francesca
AU - Tana, Francesco
AU - Bolla, Gianbattista
AU - Monzani, Anna
AU - Robuschi, Maria
AU - Mancia, Giuseppe
PY - 2005/8
Y1 - 2005/8
N2 - No agreement exists as to the mechanisms responsible for the sympathetic hyperactivity characterizing human obesity, which has been ascribed recently to a chemoreflex stimulation brought about by obstructive sleep apnea rather than to an increase in body weight, per se. In 86 middle-age normotensive subjects classified according to body mass index, waist-to-hip ratio, and apnea/hypopnea index (overnight polysomnographic evaluation) as lean and obese subjects without or with obstructive sleep apnea, we assessed via microneurography muscle sympathetic nerve traffic. The 4 groups were matched for age, gender, and blood pressure values, the 2 obese groups with and without obstructive sleep apnea showing a similar increase in body mass index (32.4 versus 32.0 kg/m 2, respectively) and waist-to-hip ratio (0.96 versus 0.95, respectively) compared with the 2 lean groups with or without obstructive sleep apnea (body mass index 24.3 versus 23.8 kg/m2 and waist-to-hip ratio 0.77 versus 0.76, respectively; P
AB - No agreement exists as to the mechanisms responsible for the sympathetic hyperactivity characterizing human obesity, which has been ascribed recently to a chemoreflex stimulation brought about by obstructive sleep apnea rather than to an increase in body weight, per se. In 86 middle-age normotensive subjects classified according to body mass index, waist-to-hip ratio, and apnea/hypopnea index (overnight polysomnographic evaluation) as lean and obese subjects without or with obstructive sleep apnea, we assessed via microneurography muscle sympathetic nerve traffic. The 4 groups were matched for age, gender, and blood pressure values, the 2 obese groups with and without obstructive sleep apnea showing a similar increase in body mass index (32.4 versus 32.0 kg/m 2, respectively) and waist-to-hip ratio (0.96 versus 0.95, respectively) compared with the 2 lean groups with or without obstructive sleep apnea (body mass index 24.3 versus 23.8 kg/m2 and waist-to-hip ratio 0.77 versus 0.76, respectively; P
KW - Baroreflex
KW - Chemoreceptors
KW - Sleep apnea syndromes
KW - Sympathetic nervous system
UR - http://www.scopus.com/inward/record.url?scp=23244437764&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23244437764&partnerID=8YFLogxK
U2 - 10.1161/01.HYP.0000174243.39897.6c
DO - 10.1161/01.HYP.0000174243.39897.6c
M3 - Article
VL - 46
SP - 321
EP - 325
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 2
ER -