Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity

Guido Grassi, Anna Facchini, Fosca Quarti Trevano, Raffaella Dell'Oro, Francesca Arenare, Francesco Tana, Gianbattista Bolla, Anna Monzani, Maria Robuschi, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


No agreement exists as to the mechanisms responsible for the sympathetic hyperactivity characterizing human obesity, which has been ascribed recently to a chemoreflex stimulation brought about by obstructive sleep apnea rather than to an increase in body weight, per se. In 86 middle-age normotensive subjects classified according to body mass index, waist-to-hip ratio, and apnea/hypopnea index (overnight polysomnographic evaluation) as lean and obese subjects without or with obstructive sleep apnea, we assessed via microneurography muscle sympathetic nerve traffic. The 4 groups were matched for age, gender, and blood pressure values, the 2 obese groups with and without obstructive sleep apnea showing a similar increase in body mass index (32.4 versus 32.0 kg/m 2, respectively) and waist-to-hip ratio (0.96 versus 0.95, respectively) compared with the 2 lean groups with or without obstructive sleep apnea (body mass index 24.3 versus 23.8 kg/m2 and waist-to-hip ratio 0.77 versus 0.76, respectively; P

Original languageEnglish
Pages (from-to)321-325
Number of pages5
Issue number2
Publication statusPublished - Aug 2005


  • Baroreflex
  • Chemoreceptors
  • Sleep apnea syndromes
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine


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