Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity

Guido Grassi, Anna Facchini, Fosca Quarti Trevano, Raffaella Dell'Oro, Francesca Arenare, Francesco Tana, Gianbattista Bolla, Anna Monzani, Maria Robuschi, Giuseppe Mancia

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

No agreement exists as to the mechanisms responsible for the sympathetic hyperactivity characterizing human obesity, which has been ascribed recently to a chemoreflex stimulation brought about by obstructive sleep apnea rather than to an increase in body weight, per se. In 86 middle-age normotensive subjects classified according to body mass index, waist-to-hip ratio, and apnea/hypopnea index (overnight polysomnographic evaluation) as lean and obese subjects without or with obstructive sleep apnea, we assessed via microneurography muscle sympathetic nerve traffic. The 4 groups were matched for age, gender, and blood pressure values, the 2 obese groups with and without obstructive sleep apnea showing a similar increase in body mass index (32.4 versus 32.0 kg/m 2, respectively) and waist-to-hip ratio (0.96 versus 0.95, respectively) compared with the 2 lean groups with or without obstructive sleep apnea (body mass index 24.3 versus 23.8 kg/m2 and waist-to-hip ratio 0.77 versus 0.76, respectively; P

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalHypertension
Volume46
Issue number2
DOIs
Publication statusPublished - Aug 2005

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Obstructive Sleep Apnea
Adrenergic Agents
Waist-Hip Ratio
Obesity
Body Mass Index
Apnea
Research Design
Body Weight
Blood Pressure
Muscles

Keywords

  • Baroreflex
  • Chemoreceptors
  • Sleep apnea syndromes
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Grassi, G., Facchini, A., Trevano, F. Q., Dell'Oro, R., Arenare, F., Tana, F., ... Mancia, G. (2005). Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity. Hypertension, 46(2), 321-325. https://doi.org/10.1161/01.HYP.0000174243.39897.6c

Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity. / Grassi, Guido; Facchini, Anna; Trevano, Fosca Quarti; Dell'Oro, Raffaella; Arenare, Francesca; Tana, Francesco; Bolla, Gianbattista; Monzani, Anna; Robuschi, Maria; Mancia, Giuseppe.

In: Hypertension, Vol. 46, No. 2, 08.2005, p. 321-325.

Research output: Contribution to journalArticle

Grassi, G, Facchini, A, Trevano, FQ, Dell'Oro, R, Arenare, F, Tana, F, Bolla, G, Monzani, A, Robuschi, M & Mancia, G 2005, 'Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity', Hypertension, vol. 46, no. 2, pp. 321-325. https://doi.org/10.1161/01.HYP.0000174243.39897.6c
Grassi, Guido ; Facchini, Anna ; Trevano, Fosca Quarti ; Dell'Oro, Raffaella ; Arenare, Francesca ; Tana, Francesco ; Bolla, Gianbattista ; Monzani, Anna ; Robuschi, Maria ; Mancia, Giuseppe. / Obstructive sleep apnea-dependent and -independent adrenergic activation in obesity. In: Hypertension. 2005 ; Vol. 46, No. 2. pp. 321-325.
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