Obstructive sleep apnea in Prader-Willi syndrome: Risks and advantages of adenotonsillectomy

Leone Giordano, Salvatore Toma, Francesca Palonta, Roberto Teggi, Marco Zucconi, Stefania Di Candia, Mario Bussi

Research output: Contribution to journalArticlepeer-review


Obstructive sleep apnea is a well-known clinical manifestation of Prader-Willi syndrome. The aim of our study is to evaluate the efficacy of adenotonsillectomy for the treatment of the disorder as well as the improvement of their post-operative quality of life. Five patients with moderate to severe obstructive sleep apneas and adenotonsillar hypertrophy of grade III-IV underwent adenotonsillectomy. Pre- and postoperative apneas and Quality of Life were assessed respectively with a polysomnography with multi-sleep latency test and with the pediatric Quality of Life questionnaire, performed before and 6 months after surgery. A decrease of apnea/hypopnea index values has been detected between pre- and post-surgery (t=2.64, P=0.005), as well as oxygen desaturation index values (t=5.51, P=0.005), multi-sleep latency test (t=4.54, P=0.01), and of the values of pediatric Quality of Life questionnaire. No correlation has been detected between body mass index and apnea/hypopnea index, oxygen desaturation index and multi-sleep latency test values pre- and post-adenotonsillectomy. A correlation has been found between multi-sleep latency test and oxygen desaturation index values post-surgery (P=0.04). No post-operative complications were observed. Our data underline the efficacy of surgery in Prader- Willi patients with adenotonsillar hypertrophy in order to improve their quality of life.

Original languageEnglish
Article number107
Pages (from-to)8-11
Number of pages4
JournalPediatria Medica e Chirurgica
Issue number2
Publication statusPublished - 2015


  • Adenotonsillar hypertrophy
  • Adenotonsillectomy
  • Obstructive sleep apnea
  • Polysomnography
  • Prader-Willi syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery


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