Abstract
The 11p15.5 chromosomal region contains one or more loci involved in congenital developmental abnormalities and in the genesis of embryonal tumors, such as Wilms' tumor, embryonal rhabdomyosarcoma, and hepatoblastoma. In these tumors, a loss of constitutive heterozygosity, selectively involving a specific parental allele, suggests both the presence of onco-suppressor genes and a phenomenon of genomic imprinting. We present evidence that both genetic events could be occasionally involved in hepatoblastoma. In fact, loss of heterozygosity at 11p15.5 could be documented in 3 of 13 patients with hepatoblastoma, and in 2 cases the paternal origin of the residual allele in the tumor was assessed. Moreover, imprinting of the paternal IGFII allele and the maternal H19 allele was confirmed in normal tissues of 5 informative patients. Finally, imprinting relaxation of IGFII was detected in the tumor tissue of 1 patient.
| Original language | English |
|---|---|
| Pages (from-to) | 732-736 |
| Number of pages | 5 |
| Journal | Journal of Cancer Research and Clinical Oncology |
| Volume | 120 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1994 |
Fingerprint
Keywords
- Hepatoblastoma
- IGFII-H19
- Loss of heterozygosity
- Loss of imprinting
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Occasional loss of constitutive heterozygosity at 11p15.5 and imprinting relaxation of the IGFII maternal allele in hepatoblastoma. / Montagna, Marco; Menin, Chiara; Chieco-Bianchi, Luigi; D'Andrea, Emma.
In: Journal of Cancer Research and Clinical Oncology, Vol. 120, No. 12, 12.1994, p. 732-736.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Occasional loss of constitutive heterozygosity at 11p15.5 and imprinting relaxation of the IGFII maternal allele in hepatoblastoma
AU - Montagna, Marco
AU - Menin, Chiara
AU - Chieco-Bianchi, Luigi
AU - D'Andrea, Emma
PY - 1994/12
Y1 - 1994/12
N2 - The 11p15.5 chromosomal region contains one or more loci involved in congenital developmental abnormalities and in the genesis of embryonal tumors, such as Wilms' tumor, embryonal rhabdomyosarcoma, and hepatoblastoma. In these tumors, a loss of constitutive heterozygosity, selectively involving a specific parental allele, suggests both the presence of onco-suppressor genes and a phenomenon of genomic imprinting. We present evidence that both genetic events could be occasionally involved in hepatoblastoma. In fact, loss of heterozygosity at 11p15.5 could be documented in 3 of 13 patients with hepatoblastoma, and in 2 cases the paternal origin of the residual allele in the tumor was assessed. Moreover, imprinting of the paternal IGFII allele and the maternal H19 allele was confirmed in normal tissues of 5 informative patients. Finally, imprinting relaxation of IGFII was detected in the tumor tissue of 1 patient.
AB - The 11p15.5 chromosomal region contains one or more loci involved in congenital developmental abnormalities and in the genesis of embryonal tumors, such as Wilms' tumor, embryonal rhabdomyosarcoma, and hepatoblastoma. In these tumors, a loss of constitutive heterozygosity, selectively involving a specific parental allele, suggests both the presence of onco-suppressor genes and a phenomenon of genomic imprinting. We present evidence that both genetic events could be occasionally involved in hepatoblastoma. In fact, loss of heterozygosity at 11p15.5 could be documented in 3 of 13 patients with hepatoblastoma, and in 2 cases the paternal origin of the residual allele in the tumor was assessed. Moreover, imprinting of the paternal IGFII allele and the maternal H19 allele was confirmed in normal tissues of 5 informative patients. Finally, imprinting relaxation of IGFII was detected in the tumor tissue of 1 patient.
KW - Hepatoblastoma
KW - IGFII-H19
KW - Loss of heterozygosity
KW - Loss of imprinting
UR - http://www.scopus.com/inward/record.url?scp=0028131720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028131720&partnerID=8YFLogxK
U2 - 10.1007/BF01194272
DO - 10.1007/BF01194272
M3 - Article
C2 - 7798299
AN - SCOPUS:0028131720
VL - 120
SP - 732
EP - 736
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
SN - 0171-5216
IS - 12
ER -