TY - JOUR
T1 - Carcinoma tiroideo occulto
AU - Boucek, J.
AU - Kastner, J.
AU - Skrivan, J.
AU - Grosso, E.
AU - Gibelli, B.
AU - Giugliano, G.
AU - Betka, J.
PY - 2009
Y1 - 2009
N2 - Some medical definitions remain the same for many years, others change due to the progress in the diagnostic tools, which are able to distinguish markers and symptoms until then undetectable. Occult thyroid carcinoma is a general term indicating clinically different situations, whereas the incidentally detected papillary thyroid microcarcinoma is the most important from the clinical point of view. It is fundamental, for therapeutic management, to determine biological parameters which would define a small group of papillary thyroid microcarcinomas with aggressive biological behaviour. The most promising genetic and molecular markers for papillary thyroid carcinoma risk stratification are discussed in this review. Preoperative evaluation of these markers, obtained through analysis of ultrasonography-guided fine needle biopsy specimens of papillary thyroid microcarcinoma, could be very valuable in guiding treatment of this type of cancer.
AB - Some medical definitions remain the same for many years, others change due to the progress in the diagnostic tools, which are able to distinguish markers and symptoms until then undetectable. Occult thyroid carcinoma is a general term indicating clinically different situations, whereas the incidentally detected papillary thyroid microcarcinoma is the most important from the clinical point of view. It is fundamental, for therapeutic management, to determine biological parameters which would define a small group of papillary thyroid microcarcinomas with aggressive biological behaviour. The most promising genetic and molecular markers for papillary thyroid carcinoma risk stratification are discussed in this review. Preoperative evaluation of these markers, obtained through analysis of ultrasonography-guided fine needle biopsy specimens of papillary thyroid microcarcinoma, could be very valuable in guiding treatment of this type of cancer.
KW - Molecular markers
KW - Occult carcinoma
KW - Papillary microcarcinoma
KW - Therapeutic strategy
KW - Thyroid
UR - http://www.scopus.com/inward/record.url?scp=77952477707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952477707&partnerID=8YFLogxK
M3 - Articolo
C2 - 20463833
AN - SCOPUS:77952477707
VL - 29
SP - 296
EP - 304
JO - Acta Otorhinolaryngologica Italica
JF - Acta Otorhinolaryngologica Italica
SN - 0392-100X
IS - 6
ER -