Occupation and cancer of the larynx: a systematic review and meta-analysis

O. Bayer, R. Cámara, S. R. Zeissig, M. Ressing, A. Dietz, L. D. Locati, H. Ramroth, S. Singer

Research output: Contribution to journalArticle

Abstract

The aim of the study was to explore the relationship between occupational exposure, defined by occupational categories and job title, and laryngeal cancer. A systematic review and meta-analysis of 21 tobacco and alcohol-adjusted case–control studies including data from 6,906 exposed cases and 10,816 exposed controls was performed to investigate the frequency of laryngeal cancer in different occupations. Job classifications were harmonized using the International Standard Classification of Occupations. Pooled odds ratios (OR [95 % confidence intervals (CI)]) were calculated for the different occupational groups. A significantly increased risk of laryngeal cancer was observed for the occupational category of ‘production-related workers, transport equipment operators, and laborers’ (OR=1.3 [1.2–1.4]); particularly at risk were occupations as: miners (OR=1.6 [1.2–2.1]), tailors (OR=1.7 [1.2–2.3]), blacksmith and toolmakers (OR=1.5 [1.2–1.7]), painters (OR=1.4 [1.1–1.9]), bricklayers and carpenters (OR=1.3 [1.2–1.5]), and transport equipment operators (OR=1.3 [1.2–1.5]). Individuals working as ‘professional, technical, and related workers’ (OR=0.7 [0.6– 0.8]), ‘administrative and managerial workers’ (OR=0.6 [0.4–0.7]), or ‘clerical and related workers’ (OR=0.8 [0.7–0.9]) had laryngeal cancer less frequently. Occupational exposure, defined by occupational categories and job title, is likely to be an independent risk factor for laryngeal cancer. Further research on specific occupations with increased risk of laryngeal cancer is warranted to explore the underlying mechanisms.

Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume273
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Laryngeal Neoplasms
Occupations
Meta-Analysis
Occupational Exposure
Equipment and Supplies
Occupational Groups
Tobacco
Odds Ratio
Alcohols
Confidence Intervals
Research

Keywords

  • ISCO
  • Job title
  • Larynx cancer
  • Occupations
  • Social epidemiology

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Occupation and cancer of the larynx : a systematic review and meta-analysis. / Bayer, O.; Cámara, R.; Zeissig, S. R.; Ressing, M.; Dietz, A.; Locati, L. D.; Ramroth, H.; Singer, S.

In: European Archives of Oto-Rhino-Laryngology, Vol. 273, No. 1, 01.01.2016, p. 9-20.

Research output: Contribution to journalArticle

Bayer, O, Cámara, R, Zeissig, SR, Ressing, M, Dietz, A, Locati, LD, Ramroth, H & Singer, S 2016, 'Occupation and cancer of the larynx: a systematic review and meta-analysis', European Archives of Oto-Rhino-Laryngology, vol. 273, no. 1, pp. 9-20. https://doi.org/10.1007/s00405-014-3321-y
Bayer, O. ; Cámara, R. ; Zeissig, S. R. ; Ressing, M. ; Dietz, A. ; Locati, L. D. ; Ramroth, H. ; Singer, S. / Occupation and cancer of the larynx : a systematic review and meta-analysis. In: European Archives of Oto-Rhino-Laryngology. 2016 ; Vol. 273, No. 1. pp. 9-20.
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