Occupation and larynx and hypopharynx cancer: A job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland

Franco Berrino, Lorenzo Richiardi, Paolo Boffetta, Jacques Estève, Isabella Belletti, Luc Raymond, Loredana Troschel, Paola Pisani, Lourdes Zubiri, Nieves Ascunce, Etienne Gubéran, Albert Tuyns, Benedetto Terracini, Franco Merletti, Lorenzo Arduini, Alberto Baldasseroni, Dario Continenza, Paolo Crosignani, Filippo Ferrario, Maurizio MacalusoCorrado Magnani, Enzo Merler

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the effect of exposure to occupational agents on the risk of hypopharyngeal/laryngeal cancer. Methods: Case-control study conducted during 1979-1982 in six centres in South Europe. An occupational history and information on exposure to non-occupational factors were collected for 1010 male cases of hypopharyngeal/laryngeal cancer as well as for 2176 population controls. The exposure to 10 occupational agents was assessed through a job-exposure matrix. As occupational histories had been collected since 1945 major analyses were restricted to subjects aged less than 55 years (315 cases and 819 controls). Results: Significant elevated risks adjusted for non-occupational variables (smoking, alcohol consumption and diet) and other occupational exposures were consistently found for organic solvents (odds ratio (OR) for ever-exposure: 1.7, 95% confidence interval: 1.1-2.5) and asbestos (OR: 1.6, 1.0-2.5). A significant positive trend for both probability of exposure and duration was found for exposure to solvents. A positive association between exposure to formaldehyde and laryngeal cancer was also suggested. No association was found for exposure to arsenic and compounds, chromium and compounds, and polycyclic aromatic hydrocarbons. Analyses restricted to subjects aged 55 or more did not show elevated risks, with the exception of wood dust (OR: 1.8, 1.3-2.7). Conclusions: In our study occupational exposure to solvents was associated with an increased risk of hypopharyngeal/laryngeal cancer. Results also provide additional evidence of an excess of risk for exposure to asbestos.

Original languageEnglish
Pages (from-to)213-223
Number of pages11
JournalCancer Causes and Control
Volume14
Issue number3
DOIs
Publication statusPublished - Apr 2003

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Hypopharynx
Laryngeal Neoplasms
Switzerland
Occupations
Spain
Italy
France
Hypopharyngeal Neoplasms
Case-Control Studies
Occupational Exposure
Asbestos
Odds Ratio
Chromium Compounds
Arsenicals
Population Control
Polycyclic Aromatic Hydrocarbons
Dust
Alcohol Drinking
Smoking
Confidence Intervals

Keywords

  • Asbestos
  • Hypopharynx cancer
  • Job exposure matrix
  • Larynx cancer
  • Occupation
  • Solvents

ASJC Scopus subject areas

  • Oncology
  • Epidemiology
  • Cancer Research

Cite this

Occupation and larynx and hypopharynx cancer : A job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland. / Berrino, Franco; Richiardi, Lorenzo; Boffetta, Paolo; Estève, Jacques; Belletti, Isabella; Raymond, Luc; Troschel, Loredana; Pisani, Paola; Zubiri, Lourdes; Ascunce, Nieves; Gubéran, Etienne; Tuyns, Albert; Terracini, Benedetto; Merletti, Franco; Arduini, Lorenzo; Baldasseroni, Alberto; Continenza, Dario; Crosignani, Paolo; Ferrario, Filippo; Macaluso, Maurizio; Magnani, Corrado; Merler, Enzo.

In: Cancer Causes and Control, Vol. 14, No. 3, 04.2003, p. 213-223.

Research output: Contribution to journalArticle

Berrino, F, Richiardi, L, Boffetta, P, Estève, J, Belletti, I, Raymond, L, Troschel, L, Pisani, P, Zubiri, L, Ascunce, N, Gubéran, E, Tuyns, A, Terracini, B, Merletti, F, Arduini, L, Baldasseroni, A, Continenza, D, Crosignani, P, Ferrario, F, Macaluso, M, Magnani, C & Merler, E 2003, 'Occupation and larynx and hypopharynx cancer: A job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland', Cancer Causes and Control, vol. 14, no. 3, pp. 213-223. https://doi.org/10.1023/A:1023661206177
Berrino, Franco ; Richiardi, Lorenzo ; Boffetta, Paolo ; Estève, Jacques ; Belletti, Isabella ; Raymond, Luc ; Troschel, Loredana ; Pisani, Paola ; Zubiri, Lourdes ; Ascunce, Nieves ; Gubéran, Etienne ; Tuyns, Albert ; Terracini, Benedetto ; Merletti, Franco ; Arduini, Lorenzo ; Baldasseroni, Alberto ; Continenza, Dario ; Crosignani, Paolo ; Ferrario, Filippo ; Macaluso, Maurizio ; Magnani, Corrado ; Merler, Enzo. / Occupation and larynx and hypopharynx cancer : A job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland. In: Cancer Causes and Control. 2003 ; Vol. 14, No. 3. pp. 213-223.
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AU - Richiardi, Lorenzo

AU - Boffetta, Paolo

AU - Estève, Jacques

AU - Belletti, Isabella

AU - Raymond, Luc

AU - Troschel, Loredana

AU - Pisani, Paola

AU - Zubiri, Lourdes

AU - Ascunce, Nieves

AU - Gubéran, Etienne

AU - Tuyns, Albert

AU - Terracini, Benedetto

AU - Merletti, Franco

AU - Arduini, Lorenzo

AU - Baldasseroni, Alberto

AU - Continenza, Dario

AU - Crosignani, Paolo

AU - Ferrario, Filippo

AU - Macaluso, Maurizio

AU - Magnani, Corrado

AU - Merler, Enzo

PY - 2003/4

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N2 - Objective: To investigate the effect of exposure to occupational agents on the risk of hypopharyngeal/laryngeal cancer. Methods: Case-control study conducted during 1979-1982 in six centres in South Europe. An occupational history and information on exposure to non-occupational factors were collected for 1010 male cases of hypopharyngeal/laryngeal cancer as well as for 2176 population controls. The exposure to 10 occupational agents was assessed through a job-exposure matrix. As occupational histories had been collected since 1945 major analyses were restricted to subjects aged less than 55 years (315 cases and 819 controls). Results: Significant elevated risks adjusted for non-occupational variables (smoking, alcohol consumption and diet) and other occupational exposures were consistently found for organic solvents (odds ratio (OR) for ever-exposure: 1.7, 95% confidence interval: 1.1-2.5) and asbestos (OR: 1.6, 1.0-2.5). A significant positive trend for both probability of exposure and duration was found for exposure to solvents. A positive association between exposure to formaldehyde and laryngeal cancer was also suggested. No association was found for exposure to arsenic and compounds, chromium and compounds, and polycyclic aromatic hydrocarbons. Analyses restricted to subjects aged 55 or more did not show elevated risks, with the exception of wood dust (OR: 1.8, 1.3-2.7). Conclusions: In our study occupational exposure to solvents was associated with an increased risk of hypopharyngeal/laryngeal cancer. Results also provide additional evidence of an excess of risk for exposure to asbestos.

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