TY - JOUR
T1 - Occupation and larynx and hypopharynx cancer
T2 - A job-exposure matrix approach in an international case-control study in France, Italy, Spain and Switzerland
AU - Berrino, Franco
AU - Richiardi, Lorenzo
AU - Boffetta, Paolo
AU - Estève, Jacques
AU - Belletti, Isabella
AU - Raymond, Luc
AU - Troschel, Loredana
AU - Pisani, Paola
AU - Zubiri, Lourdes
AU - Ascunce, Nieves
AU - Gubéran, Etienne
AU - Tuyns, Albert
AU - Terracini, Benedetto
AU - Merletti, Franco
AU - Arduini, Lorenzo
AU - Baldasseroni, Alberto
AU - Continenza, Dario
AU - Crosignani, Paolo
AU - Ferrario, Filippo
AU - Macaluso, Maurizio
AU - Magnani, Corrado
AU - Merler, Enzo
PY - 2003/4
Y1 - 2003/4
N2 - Objective: To investigate the effect of exposure to occupational agents on the risk of hypopharyngeal/laryngeal cancer. Methods: Case-control study conducted during 1979-1982 in six centres in South Europe. An occupational history and information on exposure to non-occupational factors were collected for 1010 male cases of hypopharyngeal/laryngeal cancer as well as for 2176 population controls. The exposure to 10 occupational agents was assessed through a job-exposure matrix. As occupational histories had been collected since 1945 major analyses were restricted to subjects aged less than 55 years (315 cases and 819 controls). Results: Significant elevated risks adjusted for non-occupational variables (smoking, alcohol consumption and diet) and other occupational exposures were consistently found for organic solvents (odds ratio (OR) for ever-exposure: 1.7, 95% confidence interval: 1.1-2.5) and asbestos (OR: 1.6, 1.0-2.5). A significant positive trend for both probability of exposure and duration was found for exposure to solvents. A positive association between exposure to formaldehyde and laryngeal cancer was also suggested. No association was found for exposure to arsenic and compounds, chromium and compounds, and polycyclic aromatic hydrocarbons. Analyses restricted to subjects aged 55 or more did not show elevated risks, with the exception of wood dust (OR: 1.8, 1.3-2.7). Conclusions: In our study occupational exposure to solvents was associated with an increased risk of hypopharyngeal/laryngeal cancer. Results also provide additional evidence of an excess of risk for exposure to asbestos.
AB - Objective: To investigate the effect of exposure to occupational agents on the risk of hypopharyngeal/laryngeal cancer. Methods: Case-control study conducted during 1979-1982 in six centres in South Europe. An occupational history and information on exposure to non-occupational factors were collected for 1010 male cases of hypopharyngeal/laryngeal cancer as well as for 2176 population controls. The exposure to 10 occupational agents was assessed through a job-exposure matrix. As occupational histories had been collected since 1945 major analyses were restricted to subjects aged less than 55 years (315 cases and 819 controls). Results: Significant elevated risks adjusted for non-occupational variables (smoking, alcohol consumption and diet) and other occupational exposures were consistently found for organic solvents (odds ratio (OR) for ever-exposure: 1.7, 95% confidence interval: 1.1-2.5) and asbestos (OR: 1.6, 1.0-2.5). A significant positive trend for both probability of exposure and duration was found for exposure to solvents. A positive association between exposure to formaldehyde and laryngeal cancer was also suggested. No association was found for exposure to arsenic and compounds, chromium and compounds, and polycyclic aromatic hydrocarbons. Analyses restricted to subjects aged 55 or more did not show elevated risks, with the exception of wood dust (OR: 1.8, 1.3-2.7). Conclusions: In our study occupational exposure to solvents was associated with an increased risk of hypopharyngeal/laryngeal cancer. Results also provide additional evidence of an excess of risk for exposure to asbestos.
KW - Asbestos
KW - Hypopharynx cancer
KW - Job exposure matrix
KW - Larynx cancer
KW - Occupation
KW - Solvents
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U2 - 10.1023/A:1023661206177
DO - 10.1023/A:1023661206177
M3 - Article
C2 - 12814200
AN - SCOPUS:0038662674
VL - 14
SP - 213
EP - 223
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 3
ER -