Occupation and risk of lymphoma

A multicentre prospective cohort study (EPIC)

David Neasham, Ahlem Sifi, Kaspar Rene Nielsen, Kim Overvad, Ole Raaschou-Nielsen, Anne Tjønneland, Aurelio Barricarte, Carlos A. González, Carmen Navarro, Laudina Rodriguez Suarez, Ruth C. Travis, Tim Key, Jakob Linseisen, Rudolf Kaaks, Paolo Crosignani, Franco Berrino, Stefano Rosso, Amalia Mattiello, R. C H Vermeulen, H. Bas Bueno-de-Mesquita & 18 others Göran Berglund, Jonas Manjer, Sophia Zackrisson, Goran Hallmans, Beatrice Malmer, Sheila Bingham, Kay Tee Khaw, Manuela M. Bergmann, Heiner Boeing, Antonia Trichopoulou, Giovanna Masala, Rosario Tumino, Eiliv Lund, Nadia Slimani, Pietro Ferrari, Paolo Boffetta, Paolo Vineis, Elio Riboli

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objectives: Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods: We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results: The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6). Conclusion: The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalOccupational and Environmental Medicine
Volume68
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Occupations
Lymphoma
Cohort Studies
Plasmacytoma
Prospective Studies
Multiple Myeloma
Hodgkin Disease
Non-Hodgkin's Lymphoma
Gasoline
Neoplasms
Welding
Printing
Shoes
Zoonoses
Agriculture
Proportional Hazards Models
Social Class
Meat
Industry
Teaching

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Neasham, D., Sifi, A., Nielsen, K. R., Overvad, K., Raaschou-Nielsen, O., Tjønneland, A., ... Riboli, E. (2011). Occupation and risk of lymphoma: A multicentre prospective cohort study (EPIC). Occupational and Environmental Medicine, 68(1), 77-81. https://doi.org/10.1136/oem.2009.048173

Occupation and risk of lymphoma : A multicentre prospective cohort study (EPIC). / Neasham, David; Sifi, Ahlem; Nielsen, Kaspar Rene; Overvad, Kim; Raaschou-Nielsen, Ole; Tjønneland, Anne; Barricarte, Aurelio; González, Carlos A.; Navarro, Carmen; Suarez, Laudina Rodriguez; Travis, Ruth C.; Key, Tim; Linseisen, Jakob; Kaaks, Rudolf; Crosignani, Paolo; Berrino, Franco; Rosso, Stefano; Mattiello, Amalia; Vermeulen, R. C H; Bueno-de-Mesquita, H. Bas; Berglund, Göran; Manjer, Jonas; Zackrisson, Sophia; Hallmans, Goran; Malmer, Beatrice; Bingham, Sheila; Khaw, Kay Tee; Bergmann, Manuela M.; Boeing, Heiner; Trichopoulou, Antonia; Masala, Giovanna; Tumino, Rosario; Lund, Eiliv; Slimani, Nadia; Ferrari, Pietro; Boffetta, Paolo; Vineis, Paolo; Riboli, Elio.

In: Occupational and Environmental Medicine, Vol. 68, No. 1, 01.2011, p. 77-81.

Research output: Contribution to journalArticle

Neasham, D, Sifi, A, Nielsen, KR, Overvad, K, Raaschou-Nielsen, O, Tjønneland, A, Barricarte, A, González, CA, Navarro, C, Suarez, LR, Travis, RC, Key, T, Linseisen, J, Kaaks, R, Crosignani, P, Berrino, F, Rosso, S, Mattiello, A, Vermeulen, RCH, Bueno-de-Mesquita, HB, Berglund, G, Manjer, J, Zackrisson, S, Hallmans, G, Malmer, B, Bingham, S, Khaw, KT, Bergmann, MM, Boeing, H, Trichopoulou, A, Masala, G, Tumino, R, Lund, E, Slimani, N, Ferrari, P, Boffetta, P, Vineis, P & Riboli, E 2011, 'Occupation and risk of lymphoma: A multicentre prospective cohort study (EPIC)', Occupational and Environmental Medicine, vol. 68, no. 1, pp. 77-81. https://doi.org/10.1136/oem.2009.048173
Neasham D, Sifi A, Nielsen KR, Overvad K, Raaschou-Nielsen O, Tjønneland A et al. Occupation and risk of lymphoma: A multicentre prospective cohort study (EPIC). Occupational and Environmental Medicine. 2011 Jan;68(1):77-81. https://doi.org/10.1136/oem.2009.048173
Neasham, David ; Sifi, Ahlem ; Nielsen, Kaspar Rene ; Overvad, Kim ; Raaschou-Nielsen, Ole ; Tjønneland, Anne ; Barricarte, Aurelio ; González, Carlos A. ; Navarro, Carmen ; Suarez, Laudina Rodriguez ; Travis, Ruth C. ; Key, Tim ; Linseisen, Jakob ; Kaaks, Rudolf ; Crosignani, Paolo ; Berrino, Franco ; Rosso, Stefano ; Mattiello, Amalia ; Vermeulen, R. C H ; Bueno-de-Mesquita, H. Bas ; Berglund, Göran ; Manjer, Jonas ; Zackrisson, Sophia ; Hallmans, Goran ; Malmer, Beatrice ; Bingham, Sheila ; Khaw, Kay Tee ; Bergmann, Manuela M. ; Boeing, Heiner ; Trichopoulou, Antonia ; Masala, Giovanna ; Tumino, Rosario ; Lund, Eiliv ; Slimani, Nadia ; Ferrari, Pietro ; Boffetta, Paolo ; Vineis, Paolo ; Riboli, Elio. / Occupation and risk of lymphoma : A multicentre prospective cohort study (EPIC). In: Occupational and Environmental Medicine. 2011 ; Vol. 68, No. 1. pp. 77-81.
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abstract = "Objectives: Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods: We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results: The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95{\%} CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95{\%} CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95{\%} CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95{\%} CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95{\%} CI 1.08 to 19.6). Conclusion: The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.",
author = "David Neasham and Ahlem Sifi and Nielsen, {Kaspar Rene} and Kim Overvad and Ole Raaschou-Nielsen and Anne Tj{\o}nneland and Aurelio Barricarte and Gonz{\'a}lez, {Carlos A.} and Carmen Navarro and Suarez, {Laudina Rodriguez} and Travis, {Ruth C.} and Tim Key and Jakob Linseisen and Rudolf Kaaks and Paolo Crosignani and Franco Berrino and Stefano Rosso and Amalia Mattiello and Vermeulen, {R. C H} and Bueno-de-Mesquita, {H. Bas} and G{\"o}ran Berglund and Jonas Manjer and Sophia Zackrisson and Goran Hallmans and Beatrice Malmer and Sheila Bingham and Khaw, {Kay Tee} and Bergmann, {Manuela M.} and Heiner Boeing and Antonia Trichopoulou and Giovanna Masala and Rosario Tumino and Eiliv Lund and Nadia Slimani and Pietro Ferrari and Paolo Boffetta and Paolo Vineis and Elio Riboli",
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T1 - Occupation and risk of lymphoma

T2 - A multicentre prospective cohort study (EPIC)

AU - Neasham, David

AU - Sifi, Ahlem

AU - Nielsen, Kaspar Rene

AU - Overvad, Kim

AU - Raaschou-Nielsen, Ole

AU - Tjønneland, Anne

AU - Barricarte, Aurelio

AU - González, Carlos A.

AU - Navarro, Carmen

AU - Suarez, Laudina Rodriguez

AU - Travis, Ruth C.

AU - Key, Tim

AU - Linseisen, Jakob

AU - Kaaks, Rudolf

AU - Crosignani, Paolo

AU - Berrino, Franco

AU - Rosso, Stefano

AU - Mattiello, Amalia

AU - Vermeulen, R. C H

AU - Bueno-de-Mesquita, H. Bas

AU - Berglund, Göran

AU - Manjer, Jonas

AU - Zackrisson, Sophia

AU - Hallmans, Goran

AU - Malmer, Beatrice

AU - Bingham, Sheila

AU - Khaw, Kay Tee

AU - Bergmann, Manuela M.

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Lund, Eiliv

AU - Slimani, Nadia

AU - Ferrari, Pietro

AU - Boffetta, Paolo

AU - Vineis, Paolo

AU - Riboli, Elio

PY - 2011/1

Y1 - 2011/1

N2 - Objectives: Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods: We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results: The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6). Conclusion: The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.

AB - Objectives: Evidence suggests that certain occupations and related exposures may increase the risk of malignant lymphoma. Farming, printing and paper industry, wood processing, meat handling and processing, welding, shoe and leather manufacturing and teaching profession are among the categories that have been implicated in previous studies. The relationship between occupation and malignant lymphoma has been investigated in a large European prospective study. Methods: We investigated occupational risks for lymphomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). The mean follow-up time for 348 555 subjects was 9 years (SD: 2 years). The analysis was based on 866 and 48 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) and Hodgkin's lymphoma (HL). These were identified in the EPIC subcohorts with occupational data. Data on 52 occupations were collected through standardised questionnaires. Cox proportional hazard models were used to explore the association between occupation and risk of malignant lymphoma. Results: The following occupations were positively associated with malignant NHL after adjustment for study centre, age, sex, socioeconomic status (SES), smoking and alcohol: butchers (HR=1.53, 95% CI 1.05 to 2.48, including multiple myeloma/plasmacytoma; HR=1.30, 95% CI 1.00 to 2.66, excluding multiple myeloma/plasmacytoma) and car repair workers (HR=1.50, 95% CI 1.01 to 2.00, including multiple myeloma/plasmacytoma; HR=1.51, 95% CI 1.01 to 2.31, excluding multiple myeloma/plasmacytoma). HL was associated with gasoline station occupation (HR=4.59, 95% CI 1.08 to 19.6). Conclusion: The findings in this current study of a higher risk of NHL among car repair workers and butchers and a higher risk of HL among gasoline station workers suggest a possible role from occupationally related exposures, such as solvents and zoonotic viruses, as risk factors for malignant lymphoma.

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