Occupation and risk of upper aerodigestive tract cancer: The ARCAGE study

Lorenzo Richiardi, Marine Corbin, Manuela Marron, Wolfgang Ahrens, Hermann Pohlabeln, Pagona Lagiou, Ploumitsa Minaki, Antonio Agudo, Xavier Castellsague, Alena Slamova, Miriam Schejbalova, Kristina Kjaerheim, Luigi Barzan, Renato Talamini, Gary J. MacFarlane, Tatiana V. MacFarlane, Cristina Canova, Lorenzo Simonato, David I. Conway, Patricia A. McKinneyLinda Sneddon, Peter Thomson, Ariana Znaor, Claire M. Healy, Bernard E. McCartan, Simone Benhamou, Christine Bouchardy, Mia Hashibe, Paul Brennan, Franco Merletti

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case-control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi-Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01-3.00), bricklayers (1.58, 1.05-2.37), workers employed in the erection of roofs and frames (2.62, 1.08-6.36), reinforced concreters (3.46, 1.11-10.8), dockers (2.91, 1.05-8.05) and workers employed in the construction of roads (3.03, 1.23-7.46), general construction of buildings (1.44, 1.12-1.85) and cargo handling (2.60, 1.17-5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi-Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20-10.5) and cattle and dairy farming (3.60, 1.15-11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.

Original languageEnglish
Pages (from-to)2397-2406
Number of pages10
JournalInternational Journal of Cancer
Volume130
Issue number10
DOIs
Publication statusPublished - May 15 2012

Fingerprint

Occupations
Social Adjustment
Neoplasms
Odds Ratio
Confidence Intervals
Construction Industry
Hypopharynx
Oropharynx
Mouth Neoplasms
Larynx
Agriculture
Esophagus
Mouth
Case-Control Studies
Industry
Smoking
Alcohols

Keywords

  • case-control study
  • occupational exposures
  • upper aerodigestive tract cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Richiardi, L., Corbin, M., Marron, M., Ahrens, W., Pohlabeln, H., Lagiou, P., ... Merletti, F. (2012). Occupation and risk of upper aerodigestive tract cancer: The ARCAGE study. International Journal of Cancer, 130(10), 2397-2406. https://doi.org/10.1002/ijc.26237

Occupation and risk of upper aerodigestive tract cancer : The ARCAGE study. / Richiardi, Lorenzo; Corbin, Marine; Marron, Manuela; Ahrens, Wolfgang; Pohlabeln, Hermann; Lagiou, Pagona; Minaki, Ploumitsa; Agudo, Antonio; Castellsague, Xavier; Slamova, Alena; Schejbalova, Miriam; Kjaerheim, Kristina; Barzan, Luigi; Talamini, Renato; MacFarlane, Gary J.; MacFarlane, Tatiana V.; Canova, Cristina; Simonato, Lorenzo; Conway, David I.; McKinney, Patricia A.; Sneddon, Linda; Thomson, Peter; Znaor, Ariana; Healy, Claire M.; McCartan, Bernard E.; Benhamou, Simone; Bouchardy, Christine; Hashibe, Mia; Brennan, Paul; Merletti, Franco.

In: International Journal of Cancer, Vol. 130, No. 10, 15.05.2012, p. 2397-2406.

Research output: Contribution to journalArticle

Richiardi, L, Corbin, M, Marron, M, Ahrens, W, Pohlabeln, H, Lagiou, P, Minaki, P, Agudo, A, Castellsague, X, Slamova, A, Schejbalova, M, Kjaerheim, K, Barzan, L, Talamini, R, MacFarlane, GJ, MacFarlane, TV, Canova, C, Simonato, L, Conway, DI, McKinney, PA, Sneddon, L, Thomson, P, Znaor, A, Healy, CM, McCartan, BE, Benhamou, S, Bouchardy, C, Hashibe, M, Brennan, P & Merletti, F 2012, 'Occupation and risk of upper aerodigestive tract cancer: The ARCAGE study', International Journal of Cancer, vol. 130, no. 10, pp. 2397-2406. https://doi.org/10.1002/ijc.26237
Richiardi L, Corbin M, Marron M, Ahrens W, Pohlabeln H, Lagiou P et al. Occupation and risk of upper aerodigestive tract cancer: The ARCAGE study. International Journal of Cancer. 2012 May 15;130(10):2397-2406. https://doi.org/10.1002/ijc.26237
Richiardi, Lorenzo ; Corbin, Marine ; Marron, Manuela ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Lagiou, Pagona ; Minaki, Ploumitsa ; Agudo, Antonio ; Castellsague, Xavier ; Slamova, Alena ; Schejbalova, Miriam ; Kjaerheim, Kristina ; Barzan, Luigi ; Talamini, Renato ; MacFarlane, Gary J. ; MacFarlane, Tatiana V. ; Canova, Cristina ; Simonato, Lorenzo ; Conway, David I. ; McKinney, Patricia A. ; Sneddon, Linda ; Thomson, Peter ; Znaor, Ariana ; Healy, Claire M. ; McCartan, Bernard E. ; Benhamou, Simone ; Bouchardy, Christine ; Hashibe, Mia ; Brennan, Paul ; Merletti, Franco. / Occupation and risk of upper aerodigestive tract cancer : The ARCAGE study. In: International Journal of Cancer. 2012 ; Vol. 130, No. 10. pp. 2397-2406.
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