Occupational and environmental agents as endocrine disruptors: Experimental and human evidence

A. Baccarelli, A. C. Pesatori, P. A. Bertazzi

Research output: Contribution to journalArticlepeer-review

Abstract

In the last few years great concern has arisen from the description of adverse endocrine effects of several occupational and environmental chemical agents on human and/or wildlife health. Such agents may exert their effects directly, specifically binding to hormone receptors, and/or indirectly, by altering the structure of endocrine glands and/or synthesis, releases, transport, metabolism or action of endogenous hormones. Many studies have been focused on the outcomes of the exposure to those chemicals mimicking estrogenic or androgenic actions. Nonetheless, the disruption of other hormonal pathways is not negligible. This paper reviews the experimental and human evidence of the effects of occupational and environmental chemical agents on hypothalamus-pituitary unit, pineal gland, parathyroid and calcium metabolism and adrenal glands.

Original languageEnglish
Pages (from-to)771-781
Number of pages11
JournalJournal of Endocrinological Investigation
Volume23
Issue number11
Publication statusPublished - 2000

Keywords

  • Adrenal gland
  • Endocrine disruptors
  • Environmental pollutants
  • Melatonin
  • Occupational health
  • Parathyroid
  • Pituitary
  • Thyroid
  • Xenobiotics

ASJC Scopus subject areas

  • Endocrinology

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