Occupational asthma and rhinitis caused by 1,2-benzisothiazolin-3-one in a chemical worker

G. Moscato, P. Omodeo, A. Dellabianca, M. C. Colli, F. Pugliese, C. Locatelli, J. Scibilia

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of occupational asthma and rhinitis caused by inhalation of 1,2-benzisothiazolin-3-one, an additive used as a microbicidal in detergent production, in a 26-year-old man employed in a chemical factory producing detergents. The subject's task consisted of pouring raw materials into the recipient of a machine which mixed the substances. Two months after the beginning of this job the patient complained of rhinitis and asthma at the workplace. The specific challenge test with 1,2-benzisothiazolin-3-one, one of the raw materials to which the subject was exposed, provoked an immediate prolonged asthmatic response and nasal symptoms, whereas exposure to other agents (e.g., α-amylase, alcalase or bezalkonium chloride) to which the patient was also exposed at work did not. To our knowledge this is the first case of occupational asthma and rhinitis caused by this compound.

Original languageEnglish
Pages (from-to)249-251
Number of pages3
JournalOccupational Medicine
Volume47
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • Bronchial challenge
  • Detergent industry
  • Low molecular weight compounds
  • Occupational asthma

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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