Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy

Results from the EUROPIT field study

G. M H Swaen, L. G P M Van Amelsvoort, D. Boers, E. Corsini, S. Fustinoni, T. Vergieva, C. Bosetti, S. Pennanen, J. Liesivuori, C. Colosio, H. Van Loveren

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This epidemiological study was carried out to evaluate the possible association between occupational exposure to ethylenebisdithiocarbamates (EDBC) and allergy. The study was conducted in four countries in the European Union: The Netherlands, Finland, Italy and Bulgaria. A total of 248 workers exposed to EDBC and 231 non-occupationally exposed subjects entered the study. Exposure to EDBC was measured as urinary ethylenethiourea (ETU) in urinary samples collected at baseline and after 30 days of exposure. Several effect parameters were evaluated including questionnaire data on allergy, Phadiatop, a general allergy test, and specific IgE parameters. These data were also collected at baseline and after 30 days of exposure. Cross-sectional as well as longitudinal comparisons were made, adjusted for potential confounding factors. No association was found between exposure status, EDBC levels and allergic contact dermatitis, allergic rhinitis, food allergy or atopy as measured by the Phadiatop. The prevalence of skin irritation was elevated in the Dutch field study only and is more likely a result of plant contact rather than EDBC exposure. Occupational exposure to sunlight was noted to have a protective effect on atopy in terms of IgE positivity. We conclude that the EDBC exposure levels experienced in our field study are not associated with increased prevalence of allergic symptoms or allergy.

Original languageEnglish
Pages (from-to)715-720
Number of pages6
JournalHuman and Experimental Toxicology
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Allergies
Occupational Exposure
Agriculture
Hypersensitivity
Immunoglobulin E
Ethylenethiourea
Bulgaria
Allergic Contact Dermatitis
Dermatitis
Food Hypersensitivity
Sunlight
European Union
Finland
Netherlands
Italy
Epidemiologic Studies
Skin

Keywords

  • Allergy
  • Epidemiology
  • Ethylenebisdithiocarbamate pesticides
  • Fungicides
  • Immunotoxicity
  • Occupational exposure

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy : Results from the EUROPIT field study. / Swaen, G. M H; Van Amelsvoort, L. G P M; Boers, D.; Corsini, E.; Fustinoni, S.; Vergieva, T.; Bosetti, C.; Pennanen, S.; Liesivuori, J.; Colosio, C.; Van Loveren, H.

In: Human and Experimental Toxicology, Vol. 27, No. 9, 09.2008, p. 715-720.

Research output: Contribution to journalArticle

Swaen, GMH, Van Amelsvoort, LGPM, Boers, D, Corsini, E, Fustinoni, S, Vergieva, T, Bosetti, C, Pennanen, S, Liesivuori, J, Colosio, C & Van Loveren, H 2008, 'Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy: Results from the EUROPIT field study', Human and Experimental Toxicology, vol. 27, no. 9, pp. 715-720. https://doi.org/10.1177/0960327108097433
Swaen, G. M H ; Van Amelsvoort, L. G P M ; Boers, D. ; Corsini, E. ; Fustinoni, S. ; Vergieva, T. ; Bosetti, C. ; Pennanen, S. ; Liesivuori, J. ; Colosio, C. ; Van Loveren, H. / Occupational exposure to ethylenebisdithiocarbamates in agriculture and allergy : Results from the EUROPIT field study. In: Human and Experimental Toxicology. 2008 ; Vol. 27, No. 9. pp. 715-720.
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