Abstract
Aim: The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect. Methods: Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers. Results: Individual FA levels of exposure ranged from 4.9 μg/m3 to 268.7 μg/m3. Subjects with high FA exposure showed a significant increase of the biomarker of exposure FA-HSA, but biomarkers of effect did not show any significant differences. Conclusions: A significant relationship was observed between occupational exposure to FA and a biological marker of exposure (FA-HSA). The markers of effect used (CA, MN and SCE) failed to indicate the presence of genetic damage.
| Original language | English |
|---|---|
| Pages (from-to) | 121-126 |
| Number of pages | 6 |
| Journal | Cancer Detection and Prevention |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 |
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Keywords
- Biological markers
- Chromosome aberration
- Formaldehyde
- Human serum albumin conjugate
- Laboratory personnel
- Micronuclei
- Occupational exposure
- Sister chromatid exchanges
- Smoking
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Occupational exposure to formaldehyde and biological monitoring of Research Institute workers. / Pala, Mauro; Ugolini, Donatella; Ceppi, Marcello; Rizzo, Fabio; Maiorana, Lucia; Bolognesi, Claudia; Schilirò, Tiziana; Gilli, Giorgio; Bigatti, Paola; Bono, Roberto; Vecchio, Daniela.
In: Cancer Detection and Prevention, Vol. 32, No. 2, 2008, p. 121-126.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Occupational exposure to formaldehyde and biological monitoring of Research Institute workers
AU - Pala, Mauro
AU - Ugolini, Donatella
AU - Ceppi, Marcello
AU - Rizzo, Fabio
AU - Maiorana, Lucia
AU - Bolognesi, Claudia
AU - Schilirò, Tiziana
AU - Gilli, Giorgio
AU - Bigatti, Paola
AU - Bono, Roberto
AU - Vecchio, Daniela
PY - 2008
Y1 - 2008
N2 - Aim: The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect. Methods: Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers. Results: Individual FA levels of exposure ranged from 4.9 μg/m3 to 268.7 μg/m3. Subjects with high FA exposure showed a significant increase of the biomarker of exposure FA-HSA, but biomarkers of effect did not show any significant differences. Conclusions: A significant relationship was observed between occupational exposure to FA and a biological marker of exposure (FA-HSA). The markers of effect used (CA, MN and SCE) failed to indicate the presence of genetic damage.
AB - Aim: The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect. Methods: Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers. Results: Individual FA levels of exposure ranged from 4.9 μg/m3 to 268.7 μg/m3. Subjects with high FA exposure showed a significant increase of the biomarker of exposure FA-HSA, but biomarkers of effect did not show any significant differences. Conclusions: A significant relationship was observed between occupational exposure to FA and a biological marker of exposure (FA-HSA). The markers of effect used (CA, MN and SCE) failed to indicate the presence of genetic damage.
KW - Biological markers
KW - Chromosome aberration
KW - Formaldehyde
KW - Human serum albumin conjugate
KW - Laboratory personnel
KW - Micronuclei
KW - Occupational exposure
KW - Sister chromatid exchanges
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=47749123272&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47749123272&partnerID=8YFLogxK
U2 - 10.1016/j.cdp.2008.05.003
DO - 10.1016/j.cdp.2008.05.003
M3 - Article
C2 - 18639989
AN - SCOPUS:47749123272
VL - 32
SP - 121
EP - 126
JO - Cancer Detection and Prevention
JF - Cancer Detection and Prevention
SN - 0361-090X
IS - 2
ER -