Occupational exposure to formaldehyde and biological monitoring of Research Institute workers

Mauro Pala, Donatella Ugolini, Marcello Ceppi, Fabio Rizzo, Lucia Maiorana, Claudia Bolognesi, Tiziana Schilirò, Giorgio Gilli, Paola Bigatti, Roberto Bono, Daniela Vecchio

Research output: Contribution to journalArticlepeer-review


Aim: The aim of this study was to verify the presence of a relationship between formaldehyde exposure in the work environment with biological markers of exposure and of effect. Methods: Exposure to formaldehyde (FA) of 36 workers in different laboratories of a Cancer Research Institute and biomarkers of exposure, such as formaldehyde human serum albumin conjugate (FA-HSA) and biomarkers of effect, such as chromosome aberration (CA), micronuclei (MN) and sister chromatid exchanges (SCEs) were measured in peripheral blood lymphocytes of the same workers. Results: Individual FA levels of exposure ranged from 4.9 μg/m3 to 268.7 μg/m3. Subjects with high FA exposure showed a significant increase of the biomarker of exposure FA-HSA, but biomarkers of effect did not show any significant differences. Conclusions: A significant relationship was observed between occupational exposure to FA and a biological marker of exposure (FA-HSA). The markers of effect used (CA, MN and SCE) failed to indicate the presence of genetic damage.

Original languageEnglish
Pages (from-to)121-126
Number of pages6
JournalCancer Detection and Prevention
Issue number2
Publication statusPublished - 2008


  • Biological markers
  • Chromosome aberration
  • Formaldehyde
  • Human serum albumin conjugate
  • Laboratory personnel
  • Micronuclei
  • Occupational exposure
  • Sister chromatid exchanges
  • Smoking

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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