Occupational HIV infection in a research laboratory with unknown mode of transmission: A case report

Alessandro Soria, Claudia Alteri, Gabriella Scarlatti, Ada Bertoli, Monica Tolazzi, Emanuela Balestra, Maria Concetta Bellocchi, Fabio Continenza, Luca Carioti, Mara Biasin, Daria Trabattoni, Alessandra Bandera, Francesca Ceccherini-Silberstein, Carlo Federico Perno, Andrea Gori

Research output: Contribution to journalArticlepeer-review

Abstract

A lab-worker was infected with HIV-1 in a biosafety level-2 of containment, without any apparent breach. Through full-genome sequencing and phylogenetic analyses, we could identify the source of infection in a replication-competent clone, unknowingly contaminating a safe experiment. Mode of transmission remains unclear. Caution is warranted when handling HIV-derived constructs.

Original languageEnglish
Pages (from-to)3-15
Number of pages13
JournalClinical Infectious Diseases
Volume64
Issue number6
Publication statusPublished - Jan 1 2017

Keywords

  • HIV transmission
  • HIV-1
  • Laboratory safety
  • Occupational exposure

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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