Occupational risks for lung cancer among nonsmokers

Hermann Pohlabeln, Paolo Boffetta, Wolfgang Ahrens, Franco Merletti, Antonio Agudo, Ellen Benhamou, Simone Benhamou, Irene Brüske-Hohlfeld, Gilles Ferro, Cristina Fortes, Michaela Kreuzer, Anabela Mendes, Fredrik Nyberg, Göran Pershagen, Rodolfo Saracci, Giovanni Schmid, Jack Siemiatycki, Lorenzo Simonato, Elise Whitley, Heinz Erich WichmannCarlos Winck, Paola Zambon, Karl Heinz Jöckel

Research output: Contribution to journalArticle

Abstract

We conducted a case-control study in 12 European study centers to evaluate the role of occupational risk factors among nonsmokers. We obtained detailed occupational histories from 650 nonsmoking cases (509 females/141 males) and 1,542 nonsmoking controls (1,011 females/531 males). On the basis of an a priori definition of occupations and industries that are known (list A) or suspected (list B) to be associated with lung carcinogenesis, we calculated odds ratios (ORs) for these occupations, using unconditional logistic regression models and adjusting for sex, age, and center effects. Among nonsmoking men, an excess relative risk was observed among those who had worked in list-A occupations [OR = 1.52; 95% confidence interval (CI) = 0.78-2.97] but not in list-B occupations (OR = 1.05; 95% CI = 0.60-1.83). Among nonsmoking women, there was an elevation of risk for list-A occupations (OR = 1.50; 95% CI = 0.49-4.53), although this estimate was imprecise, given that less than 1% of cases and controls were exposed. Exposure to list-B occupations was associated with an increase in relative risk (OR = 1.69; 95% CI = 1.09-2.63) in females, but not in males. Women who had been laundry workers or dry cleaners had an OR of 1.83 (95% CI = 0.98-3.40). Our findings confirm that certain occupational exposures are associated with an increased risk for lung cancer among both female and male nonsmokers; however, knowledge on occupational lung carcinogens is biased toward agents to which mainly men are exposed.

Original languageEnglish
Pages (from-to)532-538
Number of pages7
JournalEpidemiology
Volume11
Issue number5
DOIs
Publication statusPublished - 2000

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Lung Neoplasms
Odds Ratio
Occupations
Confidence Intervals
Logistic Models
Lung
Occupational Exposure
Carcinogens
Case-Control Studies
Industry
Carcinogenesis

Keywords

  • Case-control study
  • Gender
  • Lung neoplasms
  • Nonsmokers
  • Occupation

ASJC Scopus subject areas

  • Epidemiology

Cite this

Pohlabeln, H., Boffetta, P., Ahrens, W., Merletti, F., Agudo, A., Benhamou, E., ... Jöckel, K. H. (2000). Occupational risks for lung cancer among nonsmokers. Epidemiology, 11(5), 532-538. https://doi.org/10.1097/00001648-200009000-00008

Occupational risks for lung cancer among nonsmokers. / Pohlabeln, Hermann; Boffetta, Paolo; Ahrens, Wolfgang; Merletti, Franco; Agudo, Antonio; Benhamou, Ellen; Benhamou, Simone; Brüske-Hohlfeld, Irene; Ferro, Gilles; Fortes, Cristina; Kreuzer, Michaela; Mendes, Anabela; Nyberg, Fredrik; Pershagen, Göran; Saracci, Rodolfo; Schmid, Giovanni; Siemiatycki, Jack; Simonato, Lorenzo; Whitley, Elise; Wichmann, Heinz Erich; Winck, Carlos; Zambon, Paola; Jöckel, Karl Heinz.

In: Epidemiology, Vol. 11, No. 5, 2000, p. 532-538.

Research output: Contribution to journalArticle

Pohlabeln, H, Boffetta, P, Ahrens, W, Merletti, F, Agudo, A, Benhamou, E, Benhamou, S, Brüske-Hohlfeld, I, Ferro, G, Fortes, C, Kreuzer, M, Mendes, A, Nyberg, F, Pershagen, G, Saracci, R, Schmid, G, Siemiatycki, J, Simonato, L, Whitley, E, Wichmann, HE, Winck, C, Zambon, P & Jöckel, KH 2000, 'Occupational risks for lung cancer among nonsmokers', Epidemiology, vol. 11, no. 5, pp. 532-538. https://doi.org/10.1097/00001648-200009000-00008
Pohlabeln H, Boffetta P, Ahrens W, Merletti F, Agudo A, Benhamou E et al. Occupational risks for lung cancer among nonsmokers. Epidemiology. 2000;11(5):532-538. https://doi.org/10.1097/00001648-200009000-00008
Pohlabeln, Hermann ; Boffetta, Paolo ; Ahrens, Wolfgang ; Merletti, Franco ; Agudo, Antonio ; Benhamou, Ellen ; Benhamou, Simone ; Brüske-Hohlfeld, Irene ; Ferro, Gilles ; Fortes, Cristina ; Kreuzer, Michaela ; Mendes, Anabela ; Nyberg, Fredrik ; Pershagen, Göran ; Saracci, Rodolfo ; Schmid, Giovanni ; Siemiatycki, Jack ; Simonato, Lorenzo ; Whitley, Elise ; Wichmann, Heinz Erich ; Winck, Carlos ; Zambon, Paola ; Jöckel, Karl Heinz. / Occupational risks for lung cancer among nonsmokers. In: Epidemiology. 2000 ; Vol. 11, No. 5. pp. 532-538.
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AU - Benhamou, Ellen

AU - Benhamou, Simone

AU - Brüske-Hohlfeld, Irene

AU - Ferro, Gilles

AU - Fortes, Cristina

AU - Kreuzer, Michaela

AU - Mendes, Anabela

AU - Nyberg, Fredrik

AU - Pershagen, Göran

AU - Saracci, Rodolfo

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AU - Siemiatycki, Jack

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