Acrosindromi professionali. Ruolo dell'Endotelina nel vasospasmo da Cold Test: una ipotesi patogenetica.

Translated title of the contribution: Occupational syndromes of the extremities. The role of endothelin in the cold-test vasospasm: a pathogenetic hypothesis

A. Taccola, C. Aprile, L. Bacchella

Research output: Contribution to journalArticle


In 34 subjects (29 subjects vibrations exposed and 5 controls), the variations of seric levels of endothelin (Et) after Cold Test were investigated, while vasomotor modifications were monitored and recorded by forefinger volumetric pulsoplethismography. Blood sampling for Et dosage (from dorsal vein of the hand) was done in 17 subjects after 2' Cold Test and in 17 subjects after 5' Cold Test. Results: 1) Et levels are always increased after Cold Test but level increase is statistically significant only after 5' Cold Test. 2) There is no evidence of relations between Et level increase and pulsoplethismographic alterations showing acral vasospasm. It is evident that in Raynaud phenomenon Et increase is not the only factor but takes part in the occurring of this acrosyndrome. When endothelium has a reduced activity opposing cold induced vasoconstriction, seric Et increased level may represent a biohumoral factor enhancing entity and duration of vasospasm.

Original languageItalian
Pages (from-to)71-75
Number of pages5
JournalGiornale Italiano di Medicina del Lavoro
Issue number1-6
Publication statusPublished - Jan 1991


ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Rehabilitation

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