Occurence and clinical relevance of an interleukin-4 gene polymorphism im patients with multiple sclerosis

K. Vandenbroeck, A. Consiglio, M. Marrosu, D. Franciotta, M. Zaffaroni, G. Martino, L. M E Grimaldi

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Abstract

An epistatic gene interaccion has been advocated to explain disease susceptibility in Multiple Sclerosis (MS). Cytokine genes are possible candidate due to the central role played by cytokines in the regulation of the immuno-mediated pathogenetic processes leading to the central nervous system demyelination in these patients. Since interleukin (ID -4 gene polymorphisms have been associated with immune-mediated diseases, we have analysed the relationship between a variable number of tandem repeats (VNTR) polymorphisms of the IL-4 gene and clinical and physiological features of 256 sporadic MS patients and 1.15 healthy controls. Genotype frequencies were similar between MS group and healthy controls. However, in MS patients a positive and significant correlation (r=0.91; p

Original languageEnglish
Pages (from-to)78
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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