Occurence of GH deficiency in adult patients who underwent neurosurgery in the hypothalamus-pituitary area for non-functioning tumour masses

G. Corneli, R. Baldelli, C. Di Somma, S. Rovere, D. Gaia, M. Pellegrino, V. Gasco, C. Durante, S. Grottoli, A. Colao, G. Tamburrano, G. Lombardi, E. Ghigo, Gianluca Aimaretti

Research output: Contribution to journalArticlepeer-review

Abstract

Hypothalamus-pituitary tumours and their treatments (neurosurgery and/or radiotherapy) are major causes of acquired hypopituitarism. Scientific and clinical evidences show the positive effect of GH replacement therapy in severe adult GH deficiency (GHD) pointed toward the need of diagnostic screening of conditions at high risk for GHD. We screened 152 adults (82 males, 70 females; age: 52.3 ± 1.2 years, age-range: 20-80 years, BMI: 26.4 ± 0.8 kg/m2 ) in order to disclose the presence of GHD after neurosurgery for hypothalamus-pituitary tumours. The whole group (studied at least 3 months after neurosurgery) included: 111 non-functioning pituitary adenomas and 41 peri-pituitary tumours (24 craniopharyngiomas, 7 meningiomas, 5 cysts, 2 chondrosarcomas, 1 colesteatoma, 1 germinoma and 1 hemangiopericitoma). In 14 patients who underwent both neurosurgery and radiotherapy due to a tumour remnant, the somatotroph function was evaluated again 6 months after the end of radiotherapy. GHD was assumed to be shown by GH peak

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalGrowth Hormone and IGF Research
Volume13
Issue number2-3
DOIs
Publication statusPublished - Apr 2003

Keywords

  • Adulthood
  • Diagnosis
  • GH deficiency
  • Hypothalamus-pituitary tumours
  • Neurosurgery

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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