Occurrence and characterization of Pain in immune-mediated neuropathies: A multicentre prospective study

C. Pazzaglia, C. Briani, E. N. Orazio, P. Caliandro, G. Granata, P. A. Tonali, L. Padua

Research output: Contribution to journalArticlepeer-review


Background: Pain is a common symptom of peripheral neuropathies that may severely affect patients' Quality of Life. Pain questionnaires, based on verbal descriptors, are a useful way to investigate it.Methods: We performed a multicentre study through validated measures to characterize pain in a sample of consecutive patients affected by immune-mediated neuropathies.Results: Ninety-three patients were enrolled in 16 Italian centres. Based on the numeric rating scale, almost half of the patients complained of moderate pain and one-third of the patients severe pain. Overall, up to 50% of our patients with immune-mediated neuropathies complained of neuropathic pain. The most common neuropathic symptoms were paraesthesia/dysesthesia and superficial spontaneous pain. Surprisingly, also patients with neuropathies commonly thought to be painless (such as multifocal motor neuropathy) reported discomfort and painful symptoms.Conclusions: Pain questionnaires should be considered in the clinical evaluation of immune-mediated neuropathies, also when evaluating therapy efficacy, because they may provide clinicians with useful information on painful symptoms and patients' quality of life.

Original languageEnglish
Pages (from-to)177-183
Number of pages7
JournalEuropean Journal of Neurology
Issue number1
Publication statusPublished - Jan 2011


  • Immune-mediated neuropathies
  • Neuropathic pain
  • Pain questionnaires
  • Peripheral nervous system

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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