Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis

Koen Vandenbroeck, Gianvito Martino, Maria G. Marrosu, Consiglio Antonella Consiglio, Mauro Zaffaroni, Simona Vaccargiu, Diego Franciotta, Martino Ruggeri, Giancarlo Comi, Luigi M E Grimaldi

Research output: Contribution to journalArticle

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Abstract

An epistatic gene interaction has been advocated to explain disease susceptibility in multiple sclerosis (MS). Cytokine genes are possible candidates due to the central role played by cytokines in the regulation of the immune-mediated pathogenetic process leading to central nervous system demyelination in these patients. Since interleukin (IL)-4 gene polymorphisms have been associated with immune-mediated diseases, we have analysed the relationship between a variable number of tandem repeat polymorphism of the IL-4 gene and clinical and physiological features of 256 sporadic MS patients and 146 healthy controls. Genotype frequencies were similar between the MS group and healthy controls. However, in MS patients a positive and significant correlation (r = 0.91; p <0.001) was found between the carriage rate of the IL-4 B1 allele (from 0.21 to 0.36) and age of disease onset. No association was found between IL-4 alleles and disease progression, sex or ethnic background of the patients. Our results show that the IL-4 B1 allele is associated with late onset of MS and therefore might represent a modifier of age of onset rather than a susceptibility factor for patients with MS.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalJournal of Neuroimmunology
Volume76
Issue number1-2
DOIs
Publication statusPublished - Jun 1997

Fingerprint

Interleukin-4
Multiple Sclerosis
Genes
Alleles
Age of Onset
Genetic Epistasis
Cytokines
Minisatellite Repeats
Disease Susceptibility
Immune System Diseases
Demyelinating Diseases
Disease Progression
Central Nervous System
Genotype
Control Groups

Keywords

  • Genetic susceptibility
  • Interleukin-4
  • Multiple sclerosis
  • Polymorphism

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Vandenbroeck, K., Martino, G., Marrosu, M. G., Antonella Consiglio, C., Zaffaroni, M., Vaccargiu, S., ... Grimaldi, L. M. E. (1997). Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis. Journal of Neuroimmunology, 76(1-2), 189-192. https://doi.org/10.1016/S0165-5728(97)00058-1

Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis. / Vandenbroeck, Koen; Martino, Gianvito; Marrosu, Maria G.; Antonella Consiglio, Consiglio; Zaffaroni, Mauro; Vaccargiu, Simona; Franciotta, Diego; Ruggeri, Martino; Comi, Giancarlo; Grimaldi, Luigi M E.

In: Journal of Neuroimmunology, Vol. 76, No. 1-2, 06.1997, p. 189-192.

Research output: Contribution to journalArticle

Vandenbroeck, K, Martino, G, Marrosu, MG, Antonella Consiglio, C, Zaffaroni, M, Vaccargiu, S, Franciotta, D, Ruggeri, M, Comi, G & Grimaldi, LME 1997, 'Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis', Journal of Neuroimmunology, vol. 76, no. 1-2, pp. 189-192. https://doi.org/10.1016/S0165-5728(97)00058-1
Vandenbroeck, Koen ; Martino, Gianvito ; Marrosu, Maria G. ; Antonella Consiglio, Consiglio ; Zaffaroni, Mauro ; Vaccargiu, Simona ; Franciotta, Diego ; Ruggeri, Martino ; Comi, Giancarlo ; Grimaldi, Luigi M E. / Occurrence and clinical relevance of an interleukin-4 gene polymorphism in patients with multiple sclerosis. In: Journal of Neuroimmunology. 1997 ; Vol. 76, No. 1-2. pp. 189-192.
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