TY - JOUR
T1 - Occurrence and expansion of trisomy 7 in a fibroblast strain from a centenarian individual
AU - Mondello, Chiara
AU - Moralli, Daniela
AU - Franceschi, Claudio
AU - Nuzzo, Fiorella
PY - 1999/8
Y1 - 1999/8
N2 - We describe the presence of metaphases with non-random gain of one or two chromosomes in a skin fibroblast strain derived from a centenarian individual. The extra elements were chromosomes 7, X, and 18, and, among these, the most frequent was a 7. During in vitro propagation +7 cells seemed to be stable and overrode the diploid ones. After prolonged growth in culture, the cell population displayed the typical senescence signs. Our findings confirm the proneness to aneuploidy in cells from aged individuals and indicate that, while the presence of a trisomic 7 may confer a selective advantage to cells grown in vitro, it does not seem to prevent cellular senescence.
AB - We describe the presence of metaphases with non-random gain of one or two chromosomes in a skin fibroblast strain derived from a centenarian individual. The extra elements were chromosomes 7, X, and 18, and, among these, the most frequent was a 7. During in vitro propagation +7 cells seemed to be stable and overrode the diploid ones. After prolonged growth in culture, the cell population displayed the typical senescence signs. Our findings confirm the proneness to aneuploidy in cells from aged individuals and indicate that, while the presence of a trisomic 7 may confer a selective advantage to cells grown in vitro, it does not seem to prevent cellular senescence.
KW - Aneuploidy
KW - Centenarians
KW - Fibroblasts
KW - Senescence
KW - Trisomy 7
UR - http://www.scopus.com/inward/record.url?scp=0032827178&partnerID=8YFLogxK
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U2 - 10.1016/S0531-5565(99)00027-3
DO - 10.1016/S0531-5565(99)00027-3
M3 - Article
C2 - 10530795
AN - SCOPUS:0032827178
VL - 34
SP - 715
EP - 719
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 5
ER -