Occurrence and predictors of the fatigue in high-grade glioma patients

Irene Aprile, Silvia Chiesa, Luca Padua, Chiara Di Blasi, Maria Felice Arezzo, Vincenzo Valentini, Enrico Di Stasio, Mario Balducci

Research output: Contribution to journalArticlepeer-review


A better knowledge of the fatigue could be of the greatest importance for the high-grade glioma (HGG) patients, who are a unique and vulnerable population. The aim of this study was to evaluate the occurrence and the predictors of the fatigue in HGG patients, using a specific fatigue scale. The study was designed as a cross-sectional study. The study population included sixty-seven consecutive outpatients with HGG. We used these measures: Brief Fatigue Inventory, Karnofsky Performance Scale, Functional Independence Measure, Brief Psychiatric Rating Scale and Psychological Distress Inventory and SF-36, EORTC QLQ-30 and EORTC QLQ-BN20 for quality of life (QoL). Sixteen out of sixty-seven (23.9 %) patients were affected by Anaplastic Astrocytoma and 51/67 (76.1 %) by Glioblastoma Multiforme. About one-third (36.2 %) of patients had a clinically relevant fatigue (Brief Fatigue Inventory ≥3). In regression analysis, physical and mental aspects of QoL were statistically significant related with fatigue (p 

Original languageEnglish
Pages (from-to)1363-1369
Number of pages7
JournalNeurological Sciences
Issue number8
Publication statusPublished - Feb 20 2015


  • Fatigue
  • Glioma
  • Performance
  • Quality of life
  • Rehabilitation

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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