Occurrence, distribution and possible role of the regulatory peptide endothelin in the nasal mucosa

Andrea Casasco, Marco Benazzo, Marco Casasco, Antonia Icaro Cornaglia, David R. Springall, Alberto Calligaro, Eugenio Mira, Julia M. Polak

Research output: Contribution to journalArticlepeer-review


Nasal blood flow is finely regulated by local release of neurotransmitters, neuropeptides and other bioactive molecules acting via paracrine mechanisms. We have investigated the occurrence and distribution in human nasal mucosa of endothelin, a potent vasoconstrictor peptide, by immunocytochemistry and the effect of systemic administration of endothelin-1 on vascular perfusion of rabbit nasal mucosa by laser Doppler flowmetry. Endothelin-like immunoreactivity was demonstrated within vascular endothelial cells in both developing and mature human mucosa. Nasal epithelial cells and some connective tissue cells, presumed to be macrophages, also displayed specific immunostaining. In rabbits injected with endothelin-1, a potent and prolonged nasal vasoconstriction was observed. It is suggested that endothelin released locally may participate in the regulation of nasal blood flow via paracrine mechanisms. Since endothelin has growth-promoting actions on several cell types, it is also tentatively proposed that this regulatory peptide may play a role during development of the nose.

Original languageEnglish
Pages (from-to)241-247
Number of pages7
JournalCell & Tissue Research
Issue number2
Publication statusPublished - Nov 1993


  • Endothelin
  • Human
  • Immunocytochemistry
  • Laser Doppler flowmetry
  • Nasal mucosa
  • Rabbit

ASJC Scopus subject areas

  • Anatomy
  • Clinical Biochemistry
  • Cell Biology


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