Occurrence of α-adrenergic receptors in the isolated pulmonary vessels of the pig

G. D'Agostino, F. Zonta, P. Dionigi, E. Grana

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this research is to investigate α-adrenergic receptors in the isolated pig pulmonary vessels. Standard strips obtained from the pulmonary artery and vein (internal diameter 2.0-2.5 mm) were used. Noradrenaline was employed as spasmogenic substance and phentolamine was used as α-adrenolytic drug. Noradrenaline produces a dose-dependent contraction of the arterial vessels (pD2 6.7); however, no response was obtained in the vein even at the highest noradrenaline concentrations. Phentolamine induces a progressive parallel shift to the right of the dose cumulative-response curve for noradrenaline; the maximum effect is reached: the pA2 value is 7.6. These results indicate that α-adrenergic receptors are present in the pig arterial but not in the venous pulmonary vessels.

Original languageEnglish
Pages (from-to)628-629
Number of pages2
JournalIRCS Medical Science
Volume10
Issue number8
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Occurrence of α-adrenergic receptors in the isolated pulmonary vessels of the pig'. Together they form a unique fingerprint.

Cite this