The aim of this research is to investigate α-adrenergic receptors in the isolated pig pulmonary vessels. Standard strips obtained from the pulmonary artery and vein (internal diameter 2.0-2.5 mm) were used. Noradrenaline was employed as spasmogenic substance and phentolamine was used as α-adrenolytic drug. Noradrenaline produces a dose-dependent contraction of the arterial vessels (pD2 6.7); however, no response was obtained in the vein even at the highest noradrenaline concentrations. Phentolamine induces a progressive parallel shift to the right of the dose cumulative-response curve for noradrenaline; the maximum effect is reached: the pA2 value is 7.6. These results indicate that α-adrenergic receptors are present in the pig arterial but not in the venous pulmonary vessels.
|Number of pages||2|
|Journal||IRCS Medical Science|
|Publication status||Published - 1982|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)