Occurrence of chronic renal failure in liver transplantation

Monitoring of pre- and posttransplantation renal function

I. Umbro, F. Tinti, P. Piselli, F. Fiacco, V. Giannelli, V. Di Natale, A. Zavatto, M. Merli, M. Rossi, S. Ginanni Corradini, L. Poli, P. B. Berloco, A. P. Mitterhofer

Research output: Contribution to journalArticle

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Abstract

The aim of our study was to evaluate the occurrence of middle and long-term chronic renal failure (CRF) after orthotopic liver transplantation (OLT) in relation to acute renal failure (ARF). We prospectively monitored 75 patients, studying renal function on the basis of serum creatinine and glomerular filtration rate as estimated using the Modification of Diet in Renal Disease formula before as well as 1,6, and 12 months after OLT. The prevalence of ARF was 56% classified by the Acute Kidney injury Network criteria (52% stage 1, 29% stage 2, and 19% stage 3). The occurrences of CRF were 18.6% (11/59), 11.5% (6/52), and 14% (6/43) at 1, 6, and 12 months after OLT, respectively. The occurrence of CRF before OLT was 14.7%. We did not find any association between ARF and post-OLT CRF. The most relevant result of our study was the association between CRF at 6 and 12 months after transplantation with pre-OLT CRF on univariate and multivariate analysis. We suggest that evaluation of pre-OLT renal function should always be considered in the follow-up of liver transplant patients. Pre-OLT renal dysfunction must be recognized to be a risk factor for post-OLT CRF, representing important criterion to define specific therapeutic interventions to reduce patient morbidity and mortality.

Original languageEnglish
Pages (from-to)1956-1959
Number of pages4
JournalTransplantation Proceedings
Volume44
Issue number7
DOIs
Publication statusPublished - Sep 2012

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Liver Transplantation
Chronic Kidney Failure
Kidney
Acute Kidney Injury
Diet Therapy
Glomerular Filtration Rate
Creatinine
Multivariate Analysis
Transplantation
Morbidity
Transplants
Mortality
Liver
Serum

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Occurrence of chronic renal failure in liver transplantation : Monitoring of pre- and posttransplantation renal function. / Umbro, I.; Tinti, F.; Piselli, P.; Fiacco, F.; Giannelli, V.; Di Natale, V.; Zavatto, A.; Merli, M.; Rossi, M.; Ginanni Corradini, S.; Poli, L.; Berloco, P. B.; Mitterhofer, A. P.

In: Transplantation Proceedings, Vol. 44, No. 7, 09.2012, p. 1956-1959.

Research output: Contribution to journalArticle

Umbro, I, Tinti, F, Piselli, P, Fiacco, F, Giannelli, V, Di Natale, V, Zavatto, A, Merli, M, Rossi, M, Ginanni Corradini, S, Poli, L, Berloco, PB & Mitterhofer, AP 2012, 'Occurrence of chronic renal failure in liver transplantation: Monitoring of pre- and posttransplantation renal function', Transplantation Proceedings, vol. 44, no. 7, pp. 1956-1959. https://doi.org/10.1016/j.transproceed.2012.06.012
Umbro, I. ; Tinti, F. ; Piselli, P. ; Fiacco, F. ; Giannelli, V. ; Di Natale, V. ; Zavatto, A. ; Merli, M. ; Rossi, M. ; Ginanni Corradini, S. ; Poli, L. ; Berloco, P. B. ; Mitterhofer, A. P. / Occurrence of chronic renal failure in liver transplantation : Monitoring of pre- and posttransplantation renal function. In: Transplantation Proceedings. 2012 ; Vol. 44, No. 7. pp. 1956-1959.
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AU - Fiacco, F.

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AB - The aim of our study was to evaluate the occurrence of middle and long-term chronic renal failure (CRF) after orthotopic liver transplantation (OLT) in relation to acute renal failure (ARF). We prospectively monitored 75 patients, studying renal function on the basis of serum creatinine and glomerular filtration rate as estimated using the Modification of Diet in Renal Disease formula before as well as 1,6, and 12 months after OLT. The prevalence of ARF was 56% classified by the Acute Kidney injury Network criteria (52% stage 1, 29% stage 2, and 19% stage 3). The occurrences of CRF were 18.6% (11/59), 11.5% (6/52), and 14% (6/43) at 1, 6, and 12 months after OLT, respectively. The occurrence of CRF before OLT was 14.7%. We did not find any association between ARF and post-OLT CRF. The most relevant result of our study was the association between CRF at 6 and 12 months after transplantation with pre-OLT CRF on univariate and multivariate analysis. We suggest that evaluation of pre-OLT renal function should always be considered in the follow-up of liver transplant patients. Pre-OLT renal dysfunction must be recognized to be a risk factor for post-OLT CRF, representing important criterion to define specific therapeutic interventions to reduce patient morbidity and mortality.

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