Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera

B. Silvestrini, P. G. Natali, B. Catanese, G. Barillari, P. Cordiali-Fei

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The presence in the serum of albumins having a globulin-like electrophoretic mobility (globulin-like migrating blood albumins or GLIMBAL) has been determined by immunoelectrophoresis in rat and human sera. GLIMBAL have been detected occasionally (14%) in rat sera during the acute inflammation induced by yeast injection. GLIMBAL were, on the other hand, present in pathological human sera from patients with rheumatoid arthritis (50%), systemic lupus erythematosus (69%), and liver disease (17%). These data indicate that the occurrence of GLIMBAL in human sera is more frequent than previously described. Many pathological conditions are accompanied by electrophoretic changes of serum, consisting of an increase of glubulins and eventually albumin decrease; our data indicate that these changes may in some conditions reflect a process of albumin transformation rather than an increase in globulin synthesis.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalCanadian Journal of Biochemistry
Volume58
Issue number1
Publication statusPublished - 1980

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Globulins
Albumins
Serum
Immunoelectrophoresis
Serum Albumin
Systemic Lupus Erythematosus
Liver Diseases
Rheumatoid Arthritis
Yeasts
Inflammation
Injections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Silvestrini, B., Natali, P. G., Catanese, B., Barillari, G., & Cordiali-Fei, P. (1980). Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera. Canadian Journal of Biochemistry, 58(1), 89-92.

Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera. / Silvestrini, B.; Natali, P. G.; Catanese, B.; Barillari, G.; Cordiali-Fei, P.

In: Canadian Journal of Biochemistry, Vol. 58, No. 1, 1980, p. 89-92.

Research output: Contribution to journalArticle

Silvestrini, B, Natali, PG, Catanese, B, Barillari, G & Cordiali-Fei, P 1980, 'Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera', Canadian Journal of Biochemistry, vol. 58, no. 1, pp. 89-92.
Silvestrini B, Natali PG, Catanese B, Barillari G, Cordiali-Fei P. Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera. Canadian Journal of Biochemistry. 1980;58(1):89-92.
Silvestrini, B. ; Natali, P. G. ; Catanese, B. ; Barillari, G. ; Cordiali-Fei, P. / Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera. In: Canadian Journal of Biochemistry. 1980 ; Vol. 58, No. 1. pp. 89-92.
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