Abstract
The presence in the serum of albumins having a globulin-like electrophoretic mobility (globulin-like migrating blood albumins or GLIMBAL) has been determined by immunoelectrophoresis in rat and human sera. GLIMBAL have been detected occasionally (14%) in rat sera during the acute inflammation induced by yeast injection. GLIMBAL were, on the other hand, present in pathological human sera from patients with rheumatoid arthritis (50%), systemic lupus erythematosus (69%), and liver disease (17%). These data indicate that the occurrence of GLIMBAL in human sera is more frequent than previously described. Many pathological conditions are accompanied by electrophoretic changes of serum, consisting of an increase of glubulins and eventually albumin decrease; our data indicate that these changes may in some conditions reflect a process of albumin transformation rather than an increase in globulin synthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 89-92 |
| Number of pages | 4 |
| Journal | Canadian Journal of Biochemistry |
| Volume | 58 |
| Issue number | 1 |
| Publication status | Published - 1980 |
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Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera. / Silvestrini, B.; Natali, P. G.; Catanese, B.; Barillari, G.; Cordiali-Fei, P.
In: Canadian Journal of Biochemistry, Vol. 58, No. 1, 1980, p. 89-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Occurrence of globulin-like migrating blood albumins, or GLIMBAL, in pathological rat and human sera
AU - Silvestrini, B.
AU - Natali, P. G.
AU - Catanese, B.
AU - Barillari, G.
AU - Cordiali-Fei, P.
PY - 1980
Y1 - 1980
N2 - The presence in the serum of albumins having a globulin-like electrophoretic mobility (globulin-like migrating blood albumins or GLIMBAL) has been determined by immunoelectrophoresis in rat and human sera. GLIMBAL have been detected occasionally (14%) in rat sera during the acute inflammation induced by yeast injection. GLIMBAL were, on the other hand, present in pathological human sera from patients with rheumatoid arthritis (50%), systemic lupus erythematosus (69%), and liver disease (17%). These data indicate that the occurrence of GLIMBAL in human sera is more frequent than previously described. Many pathological conditions are accompanied by electrophoretic changes of serum, consisting of an increase of glubulins and eventually albumin decrease; our data indicate that these changes may in some conditions reflect a process of albumin transformation rather than an increase in globulin synthesis.
AB - The presence in the serum of albumins having a globulin-like electrophoretic mobility (globulin-like migrating blood albumins or GLIMBAL) has been determined by immunoelectrophoresis in rat and human sera. GLIMBAL have been detected occasionally (14%) in rat sera during the acute inflammation induced by yeast injection. GLIMBAL were, on the other hand, present in pathological human sera from patients with rheumatoid arthritis (50%), systemic lupus erythematosus (69%), and liver disease (17%). These data indicate that the occurrence of GLIMBAL in human sera is more frequent than previously described. Many pathological conditions are accompanied by electrophoretic changes of serum, consisting of an increase of glubulins and eventually albumin decrease; our data indicate that these changes may in some conditions reflect a process of albumin transformation rather than an increase in globulin synthesis.
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M3 - Article
VL - 58
SP - 89
EP - 92
JO - Canadian Journal of Biochemistry
JF - Canadian Journal of Biochemistry
SN - 0008-4018
IS - 1
ER -