TY - JOUR
T1 - Occurrence of human immunodeficiency virus type i (HIV-I)-specific cytolytic t cell activity in apparently uninfected children born to HIV-1-infected mothers
AU - De Maria, Andrea
AU - Cirillo, Carmela
AU - Moretta, Lorenzo
PY - 1994
Y1 - 1994
N2 - Human immunodeficiency virus type I (HIV-l)-specific cytotoxic T lymphocyte (CTL) activity against different viral antigens, including env, gag/pol, and nef, was detected in peripheral blood lymphocytes of as many as 25% of uninfected children born to HIV-I-infected mothers. The relatively high frequency of this finding in uninfected, exposed children suggests that CTL-mediated immunity may playa key role in the control or even elimination of the virus. Further characterization of this natural model of potentially protective immunity could provide new insight and suggest further strategies for the development of HIV-1 vaccines.
AB - Human immunodeficiency virus type I (HIV-l)-specific cytotoxic T lymphocyte (CTL) activity against different viral antigens, including env, gag/pol, and nef, was detected in peripheral blood lymphocytes of as many as 25% of uninfected children born to HIV-I-infected mothers. The relatively high frequency of this finding in uninfected, exposed children suggests that CTL-mediated immunity may playa key role in the control or even elimination of the virus. Further characterization of this natural model of potentially protective immunity could provide new insight and suggest further strategies for the development of HIV-1 vaccines.
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U2 - 10.1093/infdis/170.5.1296
DO - 10.1093/infdis/170.5.1296
M3 - Article
C2 - 7963731
AN - SCOPUS:0027973482
VL - 170
SP - 1296
EP - 1299
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -