Occurrence of infections in children infected with human immunodeficiency virus

Nicola Principi, Paola Marchisio, Raffaella Tornaghi, Emilia Massironi, José Onorato, Patrizia Picco, Cristina Libretti

Research output: Contribution to journalArticlepeer-review


To evaluate the occurrence of infections in asymptomatic and symptomatic human immunodeficiency virus (HlV)-infected children we performed a prospective comparative cohort study. Twenty-seven HIV-infected children were individually matched with paired immu-nocompetent controls and followed up for a total of 543 months (mean per child, 19.4 ± 11 months). Collected data were evaluated considering HIV-infected children both as a whole and as P1 and P2 patients according to the Centers for Disease Control classification. Twenty-seven HIV-infected children had 185 infectious episodes vs. 27 matched controls who experienced 118 infections. P1 children had a number of infections similar to those of normal controls (99 vs. 86) whereas P2 children had a significantly higher number of infections than did controls (86 vs. 32). Pneumonia and oral candidiasis occurred significantly more frequently in symptomatic HIV-infected children than in normal controls. Severe infections occurred almost exclusively in HIV-infected symptomatic children.

Original languageEnglish
Pages (from-to)190-193
Number of pages4
JournalPediatric Infectious Disease Journal
Issue number3
Publication statusPublished - 1991


  • Human immunodeficiency virus infection
  • Pneumonia

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Pediatrics, Perinatology, and Child Health


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