Occurrence of the same peroxidative compounds in low density lipoprotein and in atherosclerotic lesions from a homozygous familial hypercholesterolemic patient: A case report

C. Napoli, F. P. D'Armiento, G. Corso, G. Ambrosio, G. Palumbo, P. Zuliani, A. Malorni, G. Gallotta, S. Somma, A. Postiglione, M. Chiariello

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative modification of low density lipoprotein (LDL) and its byproducts may play a fundamental role in atherosclerosis. We report an in vitro analysis of LDL peroxidative compounds in an homozygous familial hypercholesterolemic (HFH) patient who subsequently died. During the autopsy, we analyzed lipids extracted directly from different atherosclerotic plaques, and we also provided an immunocytochemical analysis using the specific monoclonal antibody MDA2 (directed against malondialdeyde-lysine epitopes of oxidized LDL). The results showed that the same species of peroxidative compounds were present both in LDL in vitro and in lipids extracted directly from atherosclerotic lesions. Moreover, the immunocytochemistry analysis revealed a positive staining of atherosclerotic plaques, confirming the presence of LDL oxidation-specific epitopes. Although observation of a single case is necessarily limited, our findings are consistent with the hypothesis that oxidative modification of LDL is involved in human atherogenesis.

Original languageEnglish
Pages (from-to)77-85
Number of pages9
JournalInternational Journal of Cardiology
Volume62
Issue number1
DOIs
Publication statusPublished - Oct 31 1997

Keywords

  • Familial hypercholesterolemia
  • Immunocytochemistry
  • LDL
  • LDL oxidation
  • Oxygen radicals
  • Peroxidation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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