Occurrence over time and regression of nonalcholic fatty liver disease in type 2 diabetes

Carlo Giorda, Gabriele Forlani, Roberta Manti, Natalia Mazzella, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Giuseppina Russo, Paolo Di Bartolo, Antonio Ceriello, Piero Guida

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: This analysis was aimed to assess the incidence, regression, and correlated factors of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes, which are poorly known. Methods: Nonalcoholic fatty liver disease (defined as fatty liver index [FLI] score ≥ 60) in patients with type 2 diabetes, and related factors was investigated in a nationwide database containing information from the Italian network of diabetes clinics. A 10% variation of FLI was the cut-off considered in the analyses of a cohort of 5030 patients, which was separately conducted for those who developed, maintained, or recovered from FLI-assessed NAFLD (FLI-NAFLD) over a 3-year period. Results: At baseline, FLI-NAFLD was diagnosed in 61.3% of patients. Within the 3-year study period, FLI-NAFLD occurred in 313 patients and remitted in 410. The FLI score remained unchanged in 4307. Body-mass index (odds ratio, 1.45 95%; confidence interval, 1.35-1.55), abdominal obesity (2.11; 1.64-2.72), low HDL cholesterol levels (1.38; 1.02-1.87), and triglycerides (1.20; 1.12-1.28) all emerged as notable negative prognostic factors for the development or maintenance of FLI-NAFLD. The regression rate of FLI-NAFLD was higher among patients who managed to partially control these factors. Male sex and established organ damage, especially kidney function (1.64; 1.12-2.42), were independent risk predictors. Unlike other diabetes complications, FLI-NAFLD was more frequent among younger patients or those with a shorter duration of diabetes. Conclusions: FLI-assessed NAFLD is a dynamic condition, with about 5% of diabetic patients entering or leaving the status every year. Younger male patients with insulin resistance or organ damage have a higher risk of presenting with FLI-NAFLD at baseline, developing FLI-NAFLD within 3 years, and a lower probability of regression.

Original languageEnglish
JournalDiabetes/Metabolism Research and Reviews
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Fatty Liver
Type 2 Diabetes Mellitus
Liver Diseases
Non-alcoholic Fatty Liver Disease
Information Services
Abdominal Obesity
Diabetes Complications
HDL Cholesterol
Insulin Resistance
Triglycerides
Body Mass Index
Cohort Studies
Odds Ratio
Maintenance
Databases
Confidence Intervals
Kidney

Keywords

  • Associated factors
  • Hepatic steatosis
  • Incidence
  • Longitudinal analysis
  • Recovery
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Giorda, C., Forlani, G., Manti, R., Mazzella, N., De Cosmo, S., Rossi, M. C., ... Guida, P. (Accepted/In press). Occurrence over time and regression of nonalcholic fatty liver disease in type 2 diabetes. Diabetes/Metabolism Research and Reviews. https://doi.org/10.1002/dmrr.2878

Occurrence over time and regression of nonalcholic fatty liver disease in type 2 diabetes. / Giorda, Carlo; Forlani, Gabriele; Manti, Roberta; Mazzella, Natalia; De Cosmo, Salvatore; Rossi, Maria Chiara; Nicolucci, Antonio; Russo, Giuseppina; Di Bartolo, Paolo; Ceriello, Antonio; Guida, Piero.

In: Diabetes/Metabolism Research and Reviews, 2017.

Research output: Contribution to journalArticle

Giorda, C, Forlani, G, Manti, R, Mazzella, N, De Cosmo, S, Rossi, MC, Nicolucci, A, Russo, G, Di Bartolo, P, Ceriello, A & Guida, P 2017, 'Occurrence over time and regression of nonalcholic fatty liver disease in type 2 diabetes', Diabetes/Metabolism Research and Reviews. https://doi.org/10.1002/dmrr.2878
Giorda, Carlo ; Forlani, Gabriele ; Manti, Roberta ; Mazzella, Natalia ; De Cosmo, Salvatore ; Rossi, Maria Chiara ; Nicolucci, Antonio ; Russo, Giuseppina ; Di Bartolo, Paolo ; Ceriello, Antonio ; Guida, Piero. / Occurrence over time and regression of nonalcholic fatty liver disease in type 2 diabetes. In: Diabetes/Metabolism Research and Reviews. 2017.
@article{2dddb0e3d5a847ec9d81be472d5ca717,
title = "Occurrence over time and regression of nonalcholic fatty liver disease in type 2 diabetes",
abstract = "Background: This analysis was aimed to assess the incidence, regression, and correlated factors of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes, which are poorly known. Methods: Nonalcoholic fatty liver disease (defined as fatty liver index [FLI] score ≥ 60) in patients with type 2 diabetes, and related factors was investigated in a nationwide database containing information from the Italian network of diabetes clinics. A 10{\%} variation of FLI was the cut-off considered in the analyses of a cohort of 5030 patients, which was separately conducted for those who developed, maintained, or recovered from FLI-assessed NAFLD (FLI-NAFLD) over a 3-year period. Results: At baseline, FLI-NAFLD was diagnosed in 61.3{\%} of patients. Within the 3-year study period, FLI-NAFLD occurred in 313 patients and remitted in 410. The FLI score remained unchanged in 4307. Body-mass index (odds ratio, 1.45 95{\%}; confidence interval, 1.35-1.55), abdominal obesity (2.11; 1.64-2.72), low HDL cholesterol levels (1.38; 1.02-1.87), and triglycerides (1.20; 1.12-1.28) all emerged as notable negative prognostic factors for the development or maintenance of FLI-NAFLD. The regression rate of FLI-NAFLD was higher among patients who managed to partially control these factors. Male sex and established organ damage, especially kidney function (1.64; 1.12-2.42), were independent risk predictors. Unlike other diabetes complications, FLI-NAFLD was more frequent among younger patients or those with a shorter duration of diabetes. Conclusions: FLI-assessed NAFLD is a dynamic condition, with about 5{\%} of diabetic patients entering or leaving the status every year. Younger male patients with insulin resistance or organ damage have a higher risk of presenting with FLI-NAFLD at baseline, developing FLI-NAFLD within 3 years, and a lower probability of regression.",
keywords = "Associated factors, Hepatic steatosis, Incidence, Longitudinal analysis, Recovery, Type 2 diabetes",
author = "Carlo Giorda and Gabriele Forlani and Roberta Manti and Natalia Mazzella and {De Cosmo}, Salvatore and Rossi, {Maria Chiara} and Antonio Nicolucci and Giuseppina Russo and {Di Bartolo}, Paolo and Antonio Ceriello and Piero Guida",
year = "2017",
doi = "10.1002/dmrr.2878",
language = "English",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Occurrence over time and regression of nonalcholic fatty liver disease in type 2 diabetes

AU - Giorda, Carlo

AU - Forlani, Gabriele

AU - Manti, Roberta

AU - Mazzella, Natalia

AU - De Cosmo, Salvatore

AU - Rossi, Maria Chiara

AU - Nicolucci, Antonio

AU - Russo, Giuseppina

AU - Di Bartolo, Paolo

AU - Ceriello, Antonio

AU - Guida, Piero

PY - 2017

Y1 - 2017

N2 - Background: This analysis was aimed to assess the incidence, regression, and correlated factors of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes, which are poorly known. Methods: Nonalcoholic fatty liver disease (defined as fatty liver index [FLI] score ≥ 60) in patients with type 2 diabetes, and related factors was investigated in a nationwide database containing information from the Italian network of diabetes clinics. A 10% variation of FLI was the cut-off considered in the analyses of a cohort of 5030 patients, which was separately conducted for those who developed, maintained, or recovered from FLI-assessed NAFLD (FLI-NAFLD) over a 3-year period. Results: At baseline, FLI-NAFLD was diagnosed in 61.3% of patients. Within the 3-year study period, FLI-NAFLD occurred in 313 patients and remitted in 410. The FLI score remained unchanged in 4307. Body-mass index (odds ratio, 1.45 95%; confidence interval, 1.35-1.55), abdominal obesity (2.11; 1.64-2.72), low HDL cholesterol levels (1.38; 1.02-1.87), and triglycerides (1.20; 1.12-1.28) all emerged as notable negative prognostic factors for the development or maintenance of FLI-NAFLD. The regression rate of FLI-NAFLD was higher among patients who managed to partially control these factors. Male sex and established organ damage, especially kidney function (1.64; 1.12-2.42), were independent risk predictors. Unlike other diabetes complications, FLI-NAFLD was more frequent among younger patients or those with a shorter duration of diabetes. Conclusions: FLI-assessed NAFLD is a dynamic condition, with about 5% of diabetic patients entering or leaving the status every year. Younger male patients with insulin resistance or organ damage have a higher risk of presenting with FLI-NAFLD at baseline, developing FLI-NAFLD within 3 years, and a lower probability of regression.

AB - Background: This analysis was aimed to assess the incidence, regression, and correlated factors of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes, which are poorly known. Methods: Nonalcoholic fatty liver disease (defined as fatty liver index [FLI] score ≥ 60) in patients with type 2 diabetes, and related factors was investigated in a nationwide database containing information from the Italian network of diabetes clinics. A 10% variation of FLI was the cut-off considered in the analyses of a cohort of 5030 patients, which was separately conducted for those who developed, maintained, or recovered from FLI-assessed NAFLD (FLI-NAFLD) over a 3-year period. Results: At baseline, FLI-NAFLD was diagnosed in 61.3% of patients. Within the 3-year study period, FLI-NAFLD occurred in 313 patients and remitted in 410. The FLI score remained unchanged in 4307. Body-mass index (odds ratio, 1.45 95%; confidence interval, 1.35-1.55), abdominal obesity (2.11; 1.64-2.72), low HDL cholesterol levels (1.38; 1.02-1.87), and triglycerides (1.20; 1.12-1.28) all emerged as notable negative prognostic factors for the development or maintenance of FLI-NAFLD. The regression rate of FLI-NAFLD was higher among patients who managed to partially control these factors. Male sex and established organ damage, especially kidney function (1.64; 1.12-2.42), were independent risk predictors. Unlike other diabetes complications, FLI-NAFLD was more frequent among younger patients or those with a shorter duration of diabetes. Conclusions: FLI-assessed NAFLD is a dynamic condition, with about 5% of diabetic patients entering or leaving the status every year. Younger male patients with insulin resistance or organ damage have a higher risk of presenting with FLI-NAFLD at baseline, developing FLI-NAFLD within 3 years, and a lower probability of regression.

KW - Associated factors

KW - Hepatic steatosis

KW - Incidence

KW - Longitudinal analysis

KW - Recovery

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85011320101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011320101&partnerID=8YFLogxK

U2 - 10.1002/dmrr.2878

DO - 10.1002/dmrr.2878

M3 - Article

JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

ER -