Abstract
The Oct-4 transcription factor is expressed in embryonic stem cells and germ cells of the mouse embryo. Cells that are driven into embryonic and extraembryonic somatic differentiation lose Oct-4 expression. Oct-4 is crucial for the maintenance of the totipotency of embryonic cells at early developmental stages as demonstrated recently by homologous recombination. Since during embryogenesis Oct-4 is restricted to germ cells, it is possible that it plays a key role for the germline lineage by preventing differentiation of these cells during gastrulation. Thus, Oct-4 appears to be a key regulator of totipotency during the life cycle of mammals.
| Original language | English |
|---|---|
| Pages (from-to) | 144-152 |
| Number of pages | 9 |
| Journal | Cells Tissues Organs |
| Volume | 165 |
| Issue number | 3-4 |
| Publication status | Published - 1999 |
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Keywords
- Embryonic stem cell
- Germ cell
- Oct-4
- Transcription factor
ASJC Scopus subject areas
- Anatomy
Cite this
Oct-4 : Lessons of totipotency from embryonic stem cells. / Pesce, Maurizio; Anastassiadis, Konstantinos; Schöler, Hans R.
In: Cells Tissues Organs, Vol. 165, No. 3-4, 1999, p. 144-152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oct-4
T2 - Lessons of totipotency from embryonic stem cells
AU - Pesce, Maurizio
AU - Anastassiadis, Konstantinos
AU - Schöler, Hans R.
PY - 1999
Y1 - 1999
N2 - The Oct-4 transcription factor is expressed in embryonic stem cells and germ cells of the mouse embryo. Cells that are driven into embryonic and extraembryonic somatic differentiation lose Oct-4 expression. Oct-4 is crucial for the maintenance of the totipotency of embryonic cells at early developmental stages as demonstrated recently by homologous recombination. Since during embryogenesis Oct-4 is restricted to germ cells, it is possible that it plays a key role for the germline lineage by preventing differentiation of these cells during gastrulation. Thus, Oct-4 appears to be a key regulator of totipotency during the life cycle of mammals.
AB - The Oct-4 transcription factor is expressed in embryonic stem cells and germ cells of the mouse embryo. Cells that are driven into embryonic and extraembryonic somatic differentiation lose Oct-4 expression. Oct-4 is crucial for the maintenance of the totipotency of embryonic cells at early developmental stages as demonstrated recently by homologous recombination. Since during embryogenesis Oct-4 is restricted to germ cells, it is possible that it plays a key role for the germline lineage by preventing differentiation of these cells during gastrulation. Thus, Oct-4 appears to be a key regulator of totipotency during the life cycle of mammals.
KW - Embryonic stem cell
KW - Germ cell
KW - Oct-4
KW - Transcription factor
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UR - http://www.scopus.com/inward/citedby.url?scp=0032731129&partnerID=8YFLogxK
M3 - Article
C2 - 10592386
AN - SCOPUS:0032731129
VL - 165
SP - 144
EP - 152
JO - Cells Tissues Organs
JF - Cells Tissues Organs
SN - 1422-6405
IS - 3-4
ER -