Oct-4

Lessons of totipotency from embryonic stem cells

Maurizio Pesce, Konstantinos Anastassiadis, Hans R. Schöler

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

The Oct-4 transcription factor is expressed in embryonic stem cells and germ cells of the mouse embryo. Cells that are driven into embryonic and extraembryonic somatic differentiation lose Oct-4 expression. Oct-4 is crucial for the maintenance of the totipotency of embryonic cells at early developmental stages as demonstrated recently by homologous recombination. Since during embryogenesis Oct-4 is restricted to germ cells, it is possible that it plays a key role for the germline lineage by preventing differentiation of these cells during gastrulation. Thus, Oct-4 appears to be a key regulator of totipotency during the life cycle of mammals.

Original languageEnglish
Pages (from-to)144-152
Number of pages9
JournalCells Tissues Organs
Volume165
Issue number3-4
Publication statusPublished - 1999

Fingerprint

Embryonic Stem Cells
Germ Cells
Octamer Transcription Factor-3
Gastrulation
Homologous Recombination
Life Cycle Stages
Embryonic Development
Cell Differentiation
Mammals
Embryonic Structures
Maintenance

Keywords

  • Embryonic stem cell
  • Germ cell
  • Oct-4
  • Transcription factor

ASJC Scopus subject areas

  • Anatomy

Cite this

Pesce, M., Anastassiadis, K., & Schöler, H. R. (1999). Oct-4: Lessons of totipotency from embryonic stem cells. Cells Tissues Organs, 165(3-4), 144-152.

Oct-4 : Lessons of totipotency from embryonic stem cells. / Pesce, Maurizio; Anastassiadis, Konstantinos; Schöler, Hans R.

In: Cells Tissues Organs, Vol. 165, No. 3-4, 1999, p. 144-152.

Research output: Contribution to journalArticle

Pesce, M, Anastassiadis, K & Schöler, HR 1999, 'Oct-4: Lessons of totipotency from embryonic stem cells', Cells Tissues Organs, vol. 165, no. 3-4, pp. 144-152.
Pesce M, Anastassiadis K, Schöler HR. Oct-4: Lessons of totipotency from embryonic stem cells. Cells Tissues Organs. 1999;165(3-4):144-152.
Pesce, Maurizio ; Anastassiadis, Konstantinos ; Schöler, Hans R. / Oct-4 : Lessons of totipotency from embryonic stem cells. In: Cells Tissues Organs. 1999 ; Vol. 165, No. 3-4. pp. 144-152.
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