Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients

A double-blind randomized echo-doppler study

Paolo Buonamico, Carlo Sabba, Guadalupe Garcia-Tsao, Elsa Berardi, Gianfranco Antonica, Giovanna Ferraioli, Jonathan E. Jensen, Emanuel Lerner, Kenneth J W Taylor, Ottavio Albano, Roberto J. Groszmann

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Abstract

The effect of octreotide, a long-acting synthetic analog of somatostatin, on fasting and postprandial splanchnic hemodynamics was investigated in cirrhotic patients. Splanchnic hemodynamics were assessed using an echo-Doppler duplex system in a prospective, double-blind, placebo-controlled, crossover study performed on 2 separate days, 1 week apart, in 30 cirrhotic patients. Measurements of portal vein (PV) cross-sectional area (PVA) and mean velocity (PV-V), and of superior mesenteric artery (SMA) mean velocity (SMA-V) and pulsatility index (SMA-PI) (an index of vascular resistance) were performed at baseline, 30 minutes after octreotide (200 μg subcutaneously) or placebo administration, and 30 and 60 minutes after the ingestion of a liquid meal. In the fasted state, octreotide induced a significant decrease in PV-V (-7%) and in SMA-V (-10%) and an increase in PI (+16%). On the day of placebo administration, meal ingestion induced a significant increase in PV-V (+21%) and in SMA-V (+43%) and a decrease in PI (-21%). In contrast, meal ingestion on octreotide day induced significantly smaller increases in PV-V (+10%) and in SMAV (+18%) and a significantly smaller decrease in PI (-10%). Octreotide, although producing a mild reduction in PV-V and SMA-V in the fasted state, markedly blunts postprandial splanchnic hyperemia in cirrhotic patients.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalHepatology
Volume21
Issue number1
DOIs
Publication statusPublished - 1995

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Octreotide
Viscera
Hyperemia
Portal Vein
Superior Mesenteric Artery
Meals
Eating
Placebos
Hemodynamics
Somatostatin
Vascular Resistance
Cross-Over Studies
Fasting

ASJC Scopus subject areas

  • Hepatology

Cite this

Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients : A double-blind randomized echo-doppler study. / Buonamico, Paolo; Sabba, Carlo; Garcia-Tsao, Guadalupe; Berardi, Elsa; Antonica, Gianfranco; Ferraioli, Giovanna; Jensen, Jonathan E.; Lerner, Emanuel; Taylor, Kenneth J W; Albano, Ottavio; Groszmann, Roberto J.

In: Hepatology, Vol. 21, No. 1, 1995, p. 134-139.

Research output: Contribution to journalArticle

Buonamico, P, Sabba, C, Garcia-Tsao, G, Berardi, E, Antonica, G, Ferraioli, G, Jensen, JE, Lerner, E, Taylor, KJW, Albano, O & Groszmann, RJ 1995, 'Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double-blind randomized echo-doppler study', Hepatology, vol. 21, no. 1, pp. 134-139. https://doi.org/10.1016/0270-9139(95)90420-4
Buonamico, Paolo ; Sabba, Carlo ; Garcia-Tsao, Guadalupe ; Berardi, Elsa ; Antonica, Gianfranco ; Ferraioli, Giovanna ; Jensen, Jonathan E. ; Lerner, Emanuel ; Taylor, Kenneth J W ; Albano, Ottavio ; Groszmann, Roberto J. / Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients : A double-blind randomized echo-doppler study. In: Hepatology. 1995 ; Vol. 21, No. 1. pp. 134-139.
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abstract = "The effect of octreotide, a long-acting synthetic analog of somatostatin, on fasting and postprandial splanchnic hemodynamics was investigated in cirrhotic patients. Splanchnic hemodynamics were assessed using an echo-Doppler duplex system in a prospective, double-blind, placebo-controlled, crossover study performed on 2 separate days, 1 week apart, in 30 cirrhotic patients. Measurements of portal vein (PV) cross-sectional area (PVA) and mean velocity (PV-V), and of superior mesenteric artery (SMA) mean velocity (SMA-V) and pulsatility index (SMA-PI) (an index of vascular resistance) were performed at baseline, 30 minutes after octreotide (200 μg subcutaneously) or placebo administration, and 30 and 60 minutes after the ingestion of a liquid meal. In the fasted state, octreotide induced a significant decrease in PV-V (-7{\%}) and in SMA-V (-10{\%}) and an increase in PI (+16{\%}). On the day of placebo administration, meal ingestion induced a significant increase in PV-V (+21{\%}) and in SMA-V (+43{\%}) and a decrease in PI (-21{\%}). In contrast, meal ingestion on octreotide day induced significantly smaller increases in PV-V (+10{\%}) and in SMAV (+18{\%}) and a significantly smaller decrease in PI (-10{\%}). Octreotide, although producing a mild reduction in PV-V and SMA-V in the fasted state, markedly blunts postprandial splanchnic hyperemia in cirrhotic patients.",
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AU - Buonamico, Paolo

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AU - Garcia-Tsao, Guadalupe

AU - Berardi, Elsa

AU - Antonica, Gianfranco

AU - Ferraioli, Giovanna

AU - Jensen, Jonathan E.

AU - Lerner, Emanuel

AU - Taylor, Kenneth J W

AU - Albano, Ottavio

AU - Groszmann, Roberto J.

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