Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double-blind randomized echo-doppler study

Paolo Buonamico, Carlo Sabba, Guadalupe Garcia-Tsao, Elsa Berardi, Gianfranco Antonica, Giovanna Ferraioli, Jonathan E. Jensen, Emanuel Lerner, Kenneth J W Taylor, Ottavio Albano, Roberto J. Groszmann

Research output: Contribution to journalArticle

Abstract

The effect of octreotide, a long-acting synthetic analog of somatostatin, on fasting and postprandial splanchnic hemodynamics was investigated in cirrhotic patients. Splanchnic hemodynamics were assessed using an echo-Doppler duplex system in a prospective, double-blind, placebo-controlled, crossover study performed on 2 separate days, 1 week apart, in 30 cirrhotic patients. Measurements of portal vein (PV) cross-sectional area (PVA) and mean velocity (PV-V), and of superior mesenteric artery (SMA) mean velocity (SMA-V) and pulsatility index (SMA-PI) (an index of vascular resistance) were performed at baseline, 30 minutes after octreotide (200 μg subcutaneously) or placebo administration, and 30 and 60 minutes after the ingestion of a liquid meal. In the fasted state, octreotide induced a significant decrease in PV-V (-7%) and in SMA-V (-10%) and an increase in PI (+16%). On the day of placebo administration, meal ingestion induced a significant increase in PV-V (+21%) and in SMA-V (+43%) and a decrease in PI (-21%). In contrast, meal ingestion on octreotide day induced significantly smaller increases in PV-V (+10%) and in SMAV (+18%) and a significantly smaller decrease in PI (-10%). Octreotide, although producing a mild reduction in PV-V and SMA-V in the fasted state, markedly blunts postprandial splanchnic hyperemia in cirrhotic patients.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalHepatology
Volume21
Issue number1
DOIs
Publication statusPublished - 1995

    Fingerprint

ASJC Scopus subject areas

  • Hepatology

Cite this

Buonamico, P., Sabba, C., Garcia-Tsao, G., Berardi, E., Antonica, G., Ferraioli, G., Jensen, J. E., Lerner, E., Taylor, K. J. W., Albano, O., & Groszmann, R. J. (1995). Octreotide blunts postprandial splanchnic hyperemia in cirrhotic patients: A double-blind randomized echo-doppler study. Hepatology, 21(1), 134-139. https://doi.org/10.1016/0270-9139(95)90420-4