Ocular albinism: Evidence for a defect in an intracellular signal transduction system

M. Vittoria Schiaffino, Marilena D'Addio, Anna Alloni, Cinzia Baschirotto, Caterina Valetti, Katia Cortese, Claudia Puri, M. Teresa Bassi, Cristina Colla, Michele De Luca, Carlo Tacchetti, Andrea Ballabio

Research output: Contribution to journalArticlepeer-review

Abstract

G protein-coupled receptors (GPCRs) participate in the most common signal transduction system at the plasma membrane. The wide distribution of heterotrimeric G proteins in the internal membranes suggests that a similar signalling mechanism might also be used at intracellular locations. We provide here structural evidence that the protein product of the ocular albinism type 1 gene (OA1), a pigment cell-specific integral membrane glycoprotein, represents a novel member of the GPCR superfamily and demonstrate that it binds heterotrimeric G proteins. Moreover, we show that OA1 is not found at the plasma membrane, being instead targeted to specialized intracellular organelles, the melanosomes. Our data suggest that OA1 represents the first example of an exclusively intracellular GPCR and support the hypothesis that GPCR-mediated signal transduction systems also operate at the internal membranes in mammalian cells.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalNature Genetics
Volume23
Issue number1
DOIs
Publication statusPublished - Sep 1999

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Fingerprint Dive into the research topics of 'Ocular albinism: Evidence for a defect in an intracellular signal transduction system'. Together they form a unique fingerprint.

Cite this