Ocular involvement in nasal natural killer T-cell lymphoma

Luca Cimino, Chi Chao Chan, De Fen Shen, Luciano Masini, Fiorella Ilariucci, Maurizio Masetti, Silvia Asioli, Antonio Sartori, Luca Cappuccini

Research output: Contribution to journalArticlepeer-review


Purpose: To describe the clinical, morphologic, and immunohistochemical features of a case of paranasal natural killer/T-cell lymphoma (NKTL) with ocular involvement. Case report: In March 2005 the patient presented with a maxillary sinusitis and upper nasal obstruction. In July she underwent a nasal computed tomography (CT) scan and multiple biopsies of the granulomatous tissue in the nasal fossae. The diagnosis was NK/T non-Hodgkin's lymphoma nasal type, stage IV A. Afterwards she presented anterior uveitis. In September after the diagnosis of lymphoma the patient underwent a bone marrow biopsy and thoracic and abdominal CT scan. An ophthalmic examination including visual acuity assessment and fundoscopic examination was made. In October she started chemotherapy cycles. Maxillary CT scan and ophthalmic examinations were performed during the cycles. In January 2006 after severe recurrences of panuveitis a diagnostic vitrectomy was performed. Results: A diagnosis of T-lymphoma cells in the vitreous was made; the tumor was most likely originating from her paranasal NKTL. The condition of the patient deteriorated rapidly and she expired on February 2006. Conclusions: Nasal and paranasal sinus lymphomas are rare, but aggressive diseases with a tendency to invade tissues and spread to CNS, including the eye. Ocular manifestations prior to systemic ones may be useful to monitor the response to therapy.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalInternational Ophthalmology
Issue number4
Publication statusPublished - 2009


  • Masquerade syndrome
  • Nasal type lymphoma
  • Natural killer T-cell lymphoma
  • Serous retinal detachment

ASJC Scopus subject areas

  • Ophthalmology

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