Ocular metastases from breast carcinoma: A multicentric retrospective study

M. Amichetti, O. Caffo, E. Minatel, M. Roncadin, M. C. Valli, L. Lozza, G. Panizzoni

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Breast cancer may affect the eye and orbit by metastatic neoplastic infiltration, uvea being the most common site of presentation. Management of these cases with radiotherapy is usually gratifying with reported response rate of approximately 75%. A retrospective evaluation of cases treated in five Institutions participating in a collaborative radiation therapy group of North-Italy is reported. Fifty-four cases of metastases to the eye or orbit were referred for radiation therapy to the Departments participating in the survey in the period 1977-1995. There were 49 female patients aged between 28 and 75 years (median, 44 years) at presentation of orbital metastasis. Thirty-eight lesions (70%) were metastases to the choroid, 9 involved other parts of the eye, and 7 patients had orbital metastases. Five of the 49 patients had bilateral choroidal metastases. Radiotherapy was employed with megavoltage equipment. The median total dose delivered was 40 Gy (range, 16-60 Gy). All the patients were treated 5 times per week with fraction sizes ranging from 1.8 to 3.0 Gy (median, 2.0 Gy). Of the 43 evaluable eyes, 34 (79%) showed a definite improvement after radiotherapy. There was a stabilization of the process in 4 patients. The rest (11 lesions) were lost to detailed follow-up of the response of the eye metastases. Twelve patients experienced acute transient cherato-conjunctivitis and in a case a subconjunctival haemorrhage was observed; as late side effects, two cases of chataract were observed during a period of observation of 37 and 117 months. A median survival time of 17 months was observed. The goal of irradiation was to improve vision or at least prevent blindness and enucleation. The palliative effect of irradiation was confirmed with a response rate consistent with the data of the literature on this subject.

Original languageEnglish
Pages (from-to)761-765
Number of pages5
JournalOncology Reports
Volume7
Issue number4
Publication statusPublished - Jul 2000

Fingerprint

Retrospective Studies
Breast Neoplasms
Neoplasm Metastasis
Radiotherapy
Orbit
Uvea
Conjunctivitis
Choroid
Lost to Follow-Up
Case Management
Blindness
Italy
Observation
Hemorrhage
Equipment and Supplies
Survival

Keywords

  • Breast
  • Choroid
  • Metastasis
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Amichetti, M., Caffo, O., Minatel, E., Roncadin, M., Valli, M. C., Lozza, L., & Panizzoni, G. (2000). Ocular metastases from breast carcinoma: A multicentric retrospective study. Oncology Reports, 7(4), 761-765.

Ocular metastases from breast carcinoma : A multicentric retrospective study. / Amichetti, M.; Caffo, O.; Minatel, E.; Roncadin, M.; Valli, M. C.; Lozza, L.; Panizzoni, G.

In: Oncology Reports, Vol. 7, No. 4, 07.2000, p. 761-765.

Research output: Contribution to journalArticle

Amichetti, M, Caffo, O, Minatel, E, Roncadin, M, Valli, MC, Lozza, L & Panizzoni, G 2000, 'Ocular metastases from breast carcinoma: A multicentric retrospective study', Oncology Reports, vol. 7, no. 4, pp. 761-765.
Amichetti M, Caffo O, Minatel E, Roncadin M, Valli MC, Lozza L et al. Ocular metastases from breast carcinoma: A multicentric retrospective study. Oncology Reports. 2000 Jul;7(4):761-765.
Amichetti, M. ; Caffo, O. ; Minatel, E. ; Roncadin, M. ; Valli, M. C. ; Lozza, L. ; Panizzoni, G. / Ocular metastases from breast carcinoma : A multicentric retrospective study. In: Oncology Reports. 2000 ; Vol. 7, No. 4. pp. 761-765.
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