Ocular pathology in light chain deposition disease

B. C. Daicker, M. J. Mihatsch, E. H. Strom, G. B. Fogazzi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Light-chain deposition disease (LCDD), a rare form of monoclonal gammopathy, is characterized by deposits of amorphous light-chain material, mainly in the kidneys but also in various other organs. Here we present the first report of a light-, electron microscopic and immunohistochemical study of the globes of a patient suffering from LCDD secondary to multiple myeloma. Massive deposits of kappa light chains similar to those typically present in the kidneys were found beneath the basement membrane of the ciliary pigment epithelium, on vessels of the ciliary body, within the collagenous zones of Bruch's membrane, and in the innermost part of the choroid. The choriocapillaris in the macular area was partly obstructed by these deposits, and an exudative retinal detachment was present. Whether this detachment was the consequence of disturbed circulation of the choriocapillaris remains speculative.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalEuropean Journal of Ophthalmology
Volume5
Issue number2
Publication statusPublished - 1995

Fingerprint

Pathology
Light
Bruch Membrane
Kidney
Ciliary Body
Paraproteinemias
Choroid
Retinal Detachment
Rare Diseases
Multiple Myeloma
Basement Membrane
Epithelium
Electrons

Keywords

  • Choroid
  • Ciliary body
  • Eye
  • Light chain deposition disease
  • Multipe myeloma
  • Plasmacytoma

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Daicker, B. C., Mihatsch, M. J., Strom, E. H., & Fogazzi, G. B. (1995). Ocular pathology in light chain deposition disease. European Journal of Ophthalmology, 5(2), 75-81.

Ocular pathology in light chain deposition disease. / Daicker, B. C.; Mihatsch, M. J.; Strom, E. H.; Fogazzi, G. B.

In: European Journal of Ophthalmology, Vol. 5, No. 2, 1995, p. 75-81.

Research output: Contribution to journalArticle

Daicker, BC, Mihatsch, MJ, Strom, EH & Fogazzi, GB 1995, 'Ocular pathology in light chain deposition disease', European Journal of Ophthalmology, vol. 5, no. 2, pp. 75-81.
Daicker BC, Mihatsch MJ, Strom EH, Fogazzi GB. Ocular pathology in light chain deposition disease. European Journal of Ophthalmology. 1995;5(2):75-81.
Daicker, B. C. ; Mihatsch, M. J. ; Strom, E. H. ; Fogazzi, G. B. / Ocular pathology in light chain deposition disease. In: European Journal of Ophthalmology. 1995 ; Vol. 5, No. 2. pp. 75-81.
@article{32997bdf850749ee8fbdfc104fae6bf0,
title = "Ocular pathology in light chain deposition disease",
abstract = "Light-chain deposition disease (LCDD), a rare form of monoclonal gammopathy, is characterized by deposits of amorphous light-chain material, mainly in the kidneys but also in various other organs. Here we present the first report of a light-, electron microscopic and immunohistochemical study of the globes of a patient suffering from LCDD secondary to multiple myeloma. Massive deposits of kappa light chains similar to those typically present in the kidneys were found beneath the basement membrane of the ciliary pigment epithelium, on vessels of the ciliary body, within the collagenous zones of Bruch's membrane, and in the innermost part of the choroid. The choriocapillaris in the macular area was partly obstructed by these deposits, and an exudative retinal detachment was present. Whether this detachment was the consequence of disturbed circulation of the choriocapillaris remains speculative.",
keywords = "Choroid, Ciliary body, Eye, Light chain deposition disease, Multipe myeloma, Plasmacytoma",
author = "Daicker, {B. C.} and Mihatsch, {M. J.} and Strom, {E. H.} and Fogazzi, {G. B.}",
year = "1995",
language = "English",
volume = "5",
pages = "75--81",
journal = "European Journal of Ophthalmology",
issn = "1120-6721",
publisher = "Wichtig Publishing",
number = "2",

}

TY - JOUR

T1 - Ocular pathology in light chain deposition disease

AU - Daicker, B. C.

AU - Mihatsch, M. J.

AU - Strom, E. H.

AU - Fogazzi, G. B.

PY - 1995

Y1 - 1995

N2 - Light-chain deposition disease (LCDD), a rare form of monoclonal gammopathy, is characterized by deposits of amorphous light-chain material, mainly in the kidneys but also in various other organs. Here we present the first report of a light-, electron microscopic and immunohistochemical study of the globes of a patient suffering from LCDD secondary to multiple myeloma. Massive deposits of kappa light chains similar to those typically present in the kidneys were found beneath the basement membrane of the ciliary pigment epithelium, on vessels of the ciliary body, within the collagenous zones of Bruch's membrane, and in the innermost part of the choroid. The choriocapillaris in the macular area was partly obstructed by these deposits, and an exudative retinal detachment was present. Whether this detachment was the consequence of disturbed circulation of the choriocapillaris remains speculative.

AB - Light-chain deposition disease (LCDD), a rare form of monoclonal gammopathy, is characterized by deposits of amorphous light-chain material, mainly in the kidneys but also in various other organs. Here we present the first report of a light-, electron microscopic and immunohistochemical study of the globes of a patient suffering from LCDD secondary to multiple myeloma. Massive deposits of kappa light chains similar to those typically present in the kidneys were found beneath the basement membrane of the ciliary pigment epithelium, on vessels of the ciliary body, within the collagenous zones of Bruch's membrane, and in the innermost part of the choroid. The choriocapillaris in the macular area was partly obstructed by these deposits, and an exudative retinal detachment was present. Whether this detachment was the consequence of disturbed circulation of the choriocapillaris remains speculative.

KW - Choroid

KW - Ciliary body

KW - Eye

KW - Light chain deposition disease

KW - Multipe myeloma

KW - Plasmacytoma

UR - http://www.scopus.com/inward/record.url?scp=0029000930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029000930&partnerID=8YFLogxK

M3 - Article

C2 - 7549446

AN - SCOPUS:0029000930

VL - 5

SP - 75

EP - 81

JO - European Journal of Ophthalmology

JF - European Journal of Ophthalmology

SN - 1120-6721

IS - 2

ER -