Oculocutaneous syndrome after total biliopancreatic diversion

G. Desirello, G. Nazzari, D. Stradini, D. Friedman, E. Gianetta, N. Scopinaro, F. Crovato

Research output: Contribution to journalArticlepeer-review


Total biliopancreatic diversion is a surgical procedure for morbid obesity characterized by gastrectomy and complete diversion of biliar and pancreatic secretions without any blind loop. Fourteen patients with morbid obesity who had undergone this procedure were studied. They presented typical cutaneous lesions and/or ocular alterations. Furthermore a laboratory investigation carried out on seven of them demonstrated an average of serum vitamin A levels and of serum beta-carotene levels significantly lower than in healthy controls. Vitamin A deficiency due to impaired intestinal digestion and absorption is probably the most important pathogenetic factor. However in our study the parenteral administration of vitamin A alone (300.000 UI/die) was active only on ocular symptoms; the cutaneous lesions disappeared only after association of parenteral vitamin E (300 mg/die).

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalGiornale Italiano di Dermatologia e Venereologia
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Dermatology


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