Oesophageal adenocarcinoma: A paradigm of mechanical carcinogenesis?

Carlo La Vecchia, Eva Negri, Pagona Lagiou, Dimitrios Trichopoulos

Research output: Contribution to journalArticlepeer-review


Incidence of adenocarcinoma of the oesophagus and gastric cardia is increasing in most developed countries and strongly associated with obesity and male gender. An underlying increase in the prevalence of gastro-oesophageal reflux has generally been postulated. We suggest that the increase in frequency of reflux and the 2 associated forms of cancer can be explained by growing abdominal pressure brought about by increasing central obesity, most common among men, and sedentary lifestyle, including car use. Abdominal pressure is further accentuated mainly in men by the shift in Western male dressing towards the general use of belts.

Original languageEnglish
Pages (from-to)269-270
Number of pages2
JournalInternational Journal of Cancer
Issue number3
Publication statusPublished - Nov 20 2002


  • Carcinogenesis
  • Oesophageal adenocarcinoma
  • Risk

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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