Oesophageal cancer survival in Europe: A EUROCARE-4 study

A. T. Gavin, S. Francisci, R. Foschi, D. W. Donnelly, V. Lemmens, H. Brenner, L. A. Anderson

Research output: Contribution to journalArticle

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Abstract

Oesophageal cancer survival is poor with variation across Europe. No pan-European studies of survival differences by oesophageal cancer subtype exist. This study investigates rates and trends in oesophageal cancer survival across Europe. Data for primary malignant oesophageal cancer diagnosed in 1995-1999 and followed up to the end of 2003 was obtained from 66 cancer registries in 24 European countries. Relative survival was calculated using the Hakulinen approach. Staging data were available from 19 registries. Survival by region, gender, age, morphology and stage was investigated. Cohort analysis and the period approach were applied to investigate survival trends from 1988 to 2002 for 31 registries in 17 countries. In total 51,499 cases of oesophageal cancer diagnosed 1995-1999 were analysed. Overall, European 1- and 5-year survival rates were 33.4% (95% CI 32.9-33.9%) and 9.8% (95% CI 9.4-10.1%), respectively. Males, older patients and patients with late stage disease had poorer 1- and 5-year relative survival. Patients with squamous cell carcinoma had poorer 1-year relative survival. Regional variation in survival was observed with Central Europe above and Eastern Europe below the European pool. Survival for distant stage disease was similar across Europe while survival rates for localised disease were below the European pool in Eastern and Southern Europe. Improvement in European 1-year relative survival was reported (p=0.016). Oesophageal cancer survival was poor across Europe. Persistent regional variations in 1-year survival point to a need for a high resolution study of diagnostic and treatment practices of oesophageal cancer.

Original languageEnglish
Pages (from-to)505-512
Number of pages8
JournalCancer Epidemiology
Volume36
Issue number6
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Esophageal Neoplasms
Survival
Registries
Eastern Europe
Survival Rate
Squamous Cell Carcinoma
Cohort Studies

Keywords

  • Cancer
  • Europe
  • Oesophagus
  • Stage
  • Subtype
  • Survival
  • Trends

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology

Cite this

Gavin, A. T., Francisci, S., Foschi, R., Donnelly, D. W., Lemmens, V., Brenner, H., & Anderson, L. A. (2012). Oesophageal cancer survival in Europe: A EUROCARE-4 study. Cancer Epidemiology, 36(6), 505-512. https://doi.org/10.1016/j.canep.2012.07.009

Oesophageal cancer survival in Europe : A EUROCARE-4 study. / Gavin, A. T.; Francisci, S.; Foschi, R.; Donnelly, D. W.; Lemmens, V.; Brenner, H.; Anderson, L. A.

In: Cancer Epidemiology, Vol. 36, No. 6, 12.2012, p. 505-512.

Research output: Contribution to journalArticle

Gavin, AT, Francisci, S, Foschi, R, Donnelly, DW, Lemmens, V, Brenner, H & Anderson, LA 2012, 'Oesophageal cancer survival in Europe: A EUROCARE-4 study', Cancer Epidemiology, vol. 36, no. 6, pp. 505-512. https://doi.org/10.1016/j.canep.2012.07.009
Gavin AT, Francisci S, Foschi R, Donnelly DW, Lemmens V, Brenner H et al. Oesophageal cancer survival in Europe: A EUROCARE-4 study. Cancer Epidemiology. 2012 Dec;36(6):505-512. https://doi.org/10.1016/j.canep.2012.07.009
Gavin, A. T. ; Francisci, S. ; Foschi, R. ; Donnelly, D. W. ; Lemmens, V. ; Brenner, H. ; Anderson, L. A. / Oesophageal cancer survival in Europe : A EUROCARE-4 study. In: Cancer Epidemiology. 2012 ; Vol. 36, No. 6. pp. 505-512.
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