Oestrogen receptors and microsatellite instability in colorectal carcinoma patients

Maria Notarnicola, Roberto Gristina, Caterina Messa, Filomena Cariola, Paola Fiorente, Maria Lucia Caruso, Mattia Gentile, Alfredo Di Leo

Research output: Contribution to journalArticle

Abstract

About 10-15% of sporadic colorectal cancers show microsatellite instability (MIN), a mutator phenotype of mismatch repair genes. It seems that oestrogens may inhibit the pathway to colorectal carcinoma which involves a mismatch repair deficiency. Oestrogen receptorial status was evaluated in the neoplastic tissue and uninvolved surrounding mucosa of 17 MIN-positive and 33 MIN-negative tumours using an immunoenzymatic assay. MIN status was examined using the polymerase chain reaction and specific microsatellite markers. MIN was significantly associated with very low levels of oestrogen receptor in tumour tissue. Our findings suggest that MIN-positive tumours might lose a possible oestrogenic modulation mechanism.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalCancer Letters
Volume168
Issue number1
DOIs
Publication statusPublished - Jul 10 2001

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Keywords

  • Colorectal cancer
  • Microsatellite instability
  • Oestrogen receptor

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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