TY - JOUR
T1 - Off-pump coronary artery bypass grafting improves short-term outcomes in high-risk patients compared with on-pump coronary artery bypass grafting
T2 - Meta-analysis
AU - Kowalewski, Mariusz
AU - Pawliszak, Wojciech
AU - Malvindi, Pietro Giorgio
AU - Bokszanski, Marek Pawel
AU - Perlinski, Damian
AU - Raffa, Giuseppe Maria
AU - Kowalkowska, Magdalena Ewa
AU - Zaborowska, Katarzyna
AU - Navarese, Eliano Pio
AU - Kolodziejczak, Michalina
AU - Kowalewski, Janusz
AU - Tarelli, Giuseppe
AU - Taggart, David Paul
AU - Anisimowicz, Lech
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objectives To assess the benefits and risks of off-pump coronary artery bypass (OPCAB) versus coronary artery bypass grafting (CABG) through a meta-analysis of randomized controlled trials (RCTs), and to investigate the relationship between outcomes and patient risk profile. Methods PubMed, Embase, the Cumulative Index of Nursing and Allied Health Literature, Scopus, Web of Science, Cochrane Library, and major conference proceedings databases were searched for RCTs comparing OPCAB and CABG and reporting short-term (≤30 days) outcomes. Endpoints assessed were all-cause mortality, myocardial infarction (MI), and cerebral stroke. Results The meta-analysis included 100 studies, with a total of 19,192 subjects. There was no difference between the 2 techniques with respect to all-cause mortality and MI (odds ratio [OR], 0.88; 95% confidence interval [CI], 0.71-1.09; P =.25; I2 = 0% and OR, 0.90; 95% CI, 0.77-1.05; P =.19; I2 = 0%, respectively). OPCAB was associated with a significant 28% reduction in the odds of cerebral stroke (OR, 0.72; 95% CI, 0.56-0.92; P =.009; I2 = 0%). A significant relationship between patient risk profile and benefits from OPCAB was found in terms of all-cause mortality (P
AB - Objectives To assess the benefits and risks of off-pump coronary artery bypass (OPCAB) versus coronary artery bypass grafting (CABG) through a meta-analysis of randomized controlled trials (RCTs), and to investigate the relationship between outcomes and patient risk profile. Methods PubMed, Embase, the Cumulative Index of Nursing and Allied Health Literature, Scopus, Web of Science, Cochrane Library, and major conference proceedings databases were searched for RCTs comparing OPCAB and CABG and reporting short-term (≤30 days) outcomes. Endpoints assessed were all-cause mortality, myocardial infarction (MI), and cerebral stroke. Results The meta-analysis included 100 studies, with a total of 19,192 subjects. There was no difference between the 2 techniques with respect to all-cause mortality and MI (odds ratio [OR], 0.88; 95% confidence interval [CI], 0.71-1.09; P =.25; I2 = 0% and OR, 0.90; 95% CI, 0.77-1.05; P =.19; I2 = 0%, respectively). OPCAB was associated with a significant 28% reduction in the odds of cerebral stroke (OR, 0.72; 95% CI, 0.56-0.92; P =.009; I2 = 0%). A significant relationship between patient risk profile and benefits from OPCAB was found in terms of all-cause mortality (P
KW - cardiopulmonary bypass
KW - cerebrovascular disorders
KW - coronary disease
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U2 - 10.1016/j.jtcvs.2015.08.042
DO - 10.1016/j.jtcvs.2015.08.042
M3 - Article
C2 - 26433633
AN - SCOPUS:84957687668
VL - 151
SP - 60-77e58
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
SN - 0022-5223
IS - 1
ER -