Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation

G. Torromino, L. Autore, V. Khalil, V. Mastrorilli, M. Griguoli, A. Pignataro, E. Centofante, G. M. Biasini, V. De Turris, M. Ammassari-Teule, A. Rinaldi, A. Mele

Research output: Contribution to journalArticle

Abstract

The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum–ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-induced plasticity. These results provide new insight into the neural circuits underlying memory consolidation and establish a critical role for off-line cross-regional communication between hippocampus and ventral striatum to promote the storage of complex information.

Original languageEnglish
Article number5721
JournalNature Communications
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 1 2019

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Torromino, G., Autore, L., Khalil, V., Mastrorilli, V., Griguoli, M., Pignataro, A., ... Mele, A. (2019). Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation. Nature Communications, 10(1), [5721]. https://doi.org/10.1038/s41467-019-13703-3

Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation. / Torromino, G.; Autore, L.; Khalil, V.; Mastrorilli, V.; Griguoli, M.; Pignataro, A.; Centofante, E.; Biasini, G. M.; De Turris, V.; Ammassari-Teule, M.; Rinaldi, A.; Mele, A.

In: Nature Communications, Vol. 10, No. 1, 5721, 01.12.2019.

Research output: Contribution to journalArticle

Torromino, G, Autore, L, Khalil, V, Mastrorilli, V, Griguoli, M, Pignataro, A, Centofante, E, Biasini, GM, De Turris, V, Ammassari-Teule, M, Rinaldi, A & Mele, A 2019, 'Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation', Nature Communications, vol. 10, no. 1, 5721. https://doi.org/10.1038/s41467-019-13703-3
Torromino, G. ; Autore, L. ; Khalil, V. ; Mastrorilli, V. ; Griguoli, M. ; Pignataro, A. ; Centofante, E. ; Biasini, G. M. ; De Turris, V. ; Ammassari-Teule, M. ; Rinaldi, A. ; Mele, A. / Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation. In: Nature Communications. 2019 ; Vol. 10, No. 1.
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