Okadaic acid meet and greet: An insight into detection methods, response strategies and genotoxic effects in marine invertebrates

María Verónica Prego-Faraldo, Vanessa Valdiglesias, Josefina Méndez, José M. Eirín-López

Research output: Contribution to journalArticle

Abstract

Harmful Algal Blooms (HABs) constitute one of the most important sources of contamination in the oceans, producing high concentrations of potentially harmful biotoxins that are accumulated across the food chains. One such biotoxin, Okadaic Acid (OA), is produced by marine dinoflagellates and subsequently accumulated within the tissues of filtering marine organisms feeding on HABs, rapidly spreading to their predators in the food chain and eventually reaching human consumers causing Diarrhetic Shellfish Poisoning (DSP) syndrome. While numerous studies have thoroughly evaluated the effects of OA in mammals, the attention drawn to marine organisms in this regard has been scarce, even though they constitute primary targets for this biotoxin. With this in mind, the present work aimed to provide a timely and comprehensive insight into the current literature on the effect of OA in marine invertebrates, along with the strategies developed by these organisms to respond to its toxic effect together with the most important methods and techniques used for OA detection and evaluation.

Original languageEnglish
Pages (from-to)2829-2845
Number of pages17
JournalMarine Drugs
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • Accumulation
  • Apoptosis
  • Biotoxins
  • Depuration
  • Diarrhetic shellfish poisoning
  • Food chain
  • Genome integrity
  • Tumor

ASJC Scopus subject areas

  • Drug Discovery

Fingerprint Dive into the research topics of 'Okadaic acid meet and greet: An insight into detection methods, response strategies and genotoxic effects in marine invertebrates'. Together they form a unique fingerprint.

  • Cite this