Okadaic Acid: More than a diarrheic toxin

Vanessa Valdiglesias, María Verónica Prego-Faraldo, Eduardo Paśaro, Josefina Meńdez, Blanca Laffon

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary intoxications. OA is the main representative diarrheic shellfish poisoning (DSP) toxin and its ingestion induces gastrointestinal symptoms, although it is not considered lethal. At the molecular level, OA is a specific inhibitor of several types of serine/threonine protein phosphatases and a tumor promoter in animal carcinogenesis experiments. In the last few decades, the potential toxic effects of OA, beyond its role as a DSP toxin, have been investigated in a number of studies. Alterations in DNA and cellular components, as well as effects on immune and nervous system, and even on embryonic development, have been increasingly reported. In this manuscript, results from all these studies are compiled and reviewed to clarify the role of this toxin not only as a DSP inductor but also as cause of alterations at the cellular and molecular levels, and to highlight the relevance of biomonitoring its effects on human health. Despite further investigations are required to elucidate OA mechanisms of action, toxicokinetics, and harmful effects, there are enough evidences illustrating its toxicity, not related to DSP induction, and, consequently, supporting a revision of the current regulation on OA levels in food.

Original languageEnglish
Pages (from-to)4328-4349
Number of pages22
JournalMarine Drugs
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Okadaic Acid
Shellfish Poisoning
Marine Toxins
Shellfish
Mollusca
Environmental Monitoring
Poisons
Bivalvia
Phosphoprotein Phosphatases
Carcinogens
Nervous System
Embryonic Development
Immune System
Carcinogenesis
Fishes
Eating
Food
DNA
Health

Keywords

  • Diarrheic toxin
  • Okadaic acid
  • Phosphatase inhibition
  • Toxicity

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Valdiglesias, V., Prego-Faraldo, M. V., Paśaro, E., Meńdez, J., & Laffon, B. (2013). Okadaic Acid: More than a diarrheic toxin. Marine Drugs, 11(11), 4328-4349. https://doi.org/10.3390/md11114328

Okadaic Acid : More than a diarrheic toxin. / Valdiglesias, Vanessa; Prego-Faraldo, María Verónica; Paśaro, Eduardo; Meńdez, Josefina; Laffon, Blanca.

In: Marine Drugs, Vol. 11, No. 11, 11.2013, p. 4328-4349.

Research output: Contribution to journalArticle

Valdiglesias, V, Prego-Faraldo, MV, Paśaro, E, Meńdez, J & Laffon, B 2013, 'Okadaic Acid: More than a diarrheic toxin', Marine Drugs, vol. 11, no. 11, pp. 4328-4349. https://doi.org/10.3390/md11114328
Valdiglesias V, Prego-Faraldo MV, Paśaro E, Meńdez J, Laffon B. Okadaic Acid: More than a diarrheic toxin. Marine Drugs. 2013 Nov;11(11):4328-4349. https://doi.org/10.3390/md11114328
Valdiglesias, Vanessa ; Prego-Faraldo, María Verónica ; Paśaro, Eduardo ; Meńdez, Josefina ; Laffon, Blanca. / Okadaic Acid : More than a diarrheic toxin. In: Marine Drugs. 2013 ; Vol. 11, No. 11. pp. 4328-4349.
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