OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations

Paolo De Paoli; Michele Reitano; Sandro Battistin; Gianludovico Molaro; Gianfranco Santini

doi:10.1159/000206092

OKT4⁺ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations

Paolo De Paoli, Michele Reitano, Sandro Battistin, Gianludovico Molaro, Gianfranco Santini

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4⁺⁺ Leu8⁺⁺ Leu9⁺, OKT4⁺⁺ Leu8+ Leu9^- and the OKT4⁺⁺ Leu9++ Leu8^- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.

Original language	English
Pages (from-to)	89-91
Number of pages	3
Journal	Acta Haematologica
Volume	75
Issue number	2
DOIs	https://doi.org/10.1159/000206092
Publication status	Published - 1986

Keywords

Double-labelling studies
Lymphocytes
T lymphocytic leukaemia, chronic

ASJC Scopus subject areas

Hematology

Access to Document

10.1159/000206092

Cite this

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title = "OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations",

abstract = "Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4++ Leu8++ Leu9+, OKT4++ Leu8+ Leu9- and the OKT4++ Leu9++ Leu8- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.",

keywords = "Double-labelling studies, Lymphocytes, T lymphocytic leukaemia, chronic",

author = "{De Paoli}, Paolo and Michele Reitano and Sandro Battistin and Gianludovico Molaro and Gianfranco Santini",

year = "1986",

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T1 - OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations

AU - De Paoli, Paolo

AU - Reitano, Michele

AU - Battistin, Sandro

AU - Molaro, Gianludovico

AU - Santini, Gianfranco

PY - 1986

Y1 - 1986

N2 - Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4++ Leu8++ Leu9+, OKT4++ Leu8+ Leu9- and the OKT4++ Leu9++ Leu8- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.

AB - Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4++ Leu8++ Leu9+, OKT4++ Leu8+ Leu9- and the OKT4++ Leu9++ Leu8- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.

KW - Double-labelling studies

KW - Lymphocytes

KW - T lymphocytic leukaemia, chronic

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