OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations

Paolo De Paoli, Michele Reitano, Sandro Battistin, Gianludovico Molaro, Gianfranco Santini

Research output: Contribution to journalArticle

Abstract

Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4++ Leu8++ Leu9+, OKT4++ Leu8+ Leu9- and the OKT4++ Leu9++ Leu8- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.

Original languageEnglish
Pages (from-to)89-91
Number of pages3
JournalActa Haematologica
Volume75
Issue number2
DOIs
Publication statusPublished - 1986

Fingerprint

HTLV-I Antibodies
T-Cell Prolymphocytic Leukemia
B-Cell Chronic Lymphocytic Leukemia
Leukemia
Fluorescence
Monoclonal Antibodies
T-Lymphocytes

Keywords

  • Double-labelling studies
  • Lymphocytes
  • T lymphocytic leukaemia, chronic

ASJC Scopus subject areas

  • Hematology

Cite this

OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations. / De Paoli, Paolo; Reitano, Michele; Battistin, Sandro; Molaro, Gianludovico; Santini, Gianfranco.

In: Acta Haematologica, Vol. 75, No. 2, 1986, p. 89-91.

Research output: Contribution to journalArticle

De Paoli, Paolo ; Reitano, Michele ; Battistin, Sandro ; Molaro, Gianludovico ; Santini, Gianfranco. / OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations. In: Acta Haematologica. 1986 ; Vol. 75, No. 2. pp. 89-91.
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