Abstract
Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4++ Leu8++ Leu9+, OKT4++ Leu8+ Leu9- and the OKT4++ Leu9++ Leu8- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.
| Original language | English |
|---|---|
| Pages (from-to) | 89-91 |
| Number of pages | 3 |
| Journal | Acta Haematologica |
| Volume | 75 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1986 |
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Keywords
- Double-labelling studies
- Lymphocytes
- T lymphocytic leukaemia, chronic
ASJC Scopus subject areas
- Hematology
Cite this
OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations. / De Paoli, Paolo; Reitano, Michele; Battistin, Sandro; Molaro, Gianludovico; Santini, Gianfranco.
In: Acta Haematologica, Vol. 75, No. 2, 1986, p. 89-91.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - OKT4+ chronic lymphocytic leukaemia cells display different reactivity with selected monoclonal antibody combinations
AU - De Paoli, Paolo
AU - Reitano, Michele
AU - Battistin, Sandro
AU - Molaro, Gianludovico
AU - Santini, Gianfranco
PY - 1986
Y1 - 1986
N2 - Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4++ Leu8++ Leu9+, OKT4++ Leu8+ Leu9- and the OKT4++ Leu9++ Leu8- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.
AB - Four cases of chronic T lymphocytic leukaemia are characterized by selected monoclonal antibody combinations and double-fluorescence studies. We found 3 possible combinations: OKT4++ Leu8++ Leu9+, OKT4++ Leu8+ Leu9- and the OKT4++ Leu9++ Leu8- phentotypes are correlated with different biological aspects of the disease. No markers of T cell activation were found, and serological examinations did not reveal anti-HTLV-I antibodies. In considering a larger number of patients, multiparametric analysis could be useful to better classify this heterogeneous type of leukaemia.
KW - Double-labelling studies
KW - Lymphocytes
KW - T lymphocytic leukaemia, chronic
UR - http://www.scopus.com/inward/record.url?scp=0022469483&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022469483&partnerID=8YFLogxK
U2 - 10.1159/000206092
DO - 10.1159/000206092
M3 - Article
C2 - 3090828
AN - SCOPUS:0022469483
VL - 75
SP - 89
EP - 91
JO - Acta Haematologica
JF - Acta Haematologica
SN - 0001-5792
IS - 2
ER -