Olanzapine-induced neutropenia in a patient with systemiclupus erythematosus: A role of FcγRIIIb polymorphism?

M. Salviati, E. Ortona, T. Colasanti, A. Francia, S. Pontecorvo, R. Delle Chiaie

Research output: Contribution to journalArticle

Abstract

In this study, we report the case of a Chinese patient with systemic lupus erythematosus (SLE) who developed neutropenia after treatment by olanzapine for the SLE-related psychiatric symptoms. The relationship between agranulocytosis, SLE and olanzapine is still unknown. Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor, constitutively expressed only by neutrophils; NA1 and NA2 have been identified as representing polymorphisms of FcγRIIIb. NA1 is associated with the incidence of autoimmune neutropenia and is particularly frequent in Asiatic ethnic groups. The Chinese patient resulted to be homozygous for NA1. We suggest that the presence of NA1 allele may be a predisposing factor to olanzapine-induced agranulocytosis in patients with SLE. Hence, the analysis of FcγRIIIb polymorphism should be investigated in other cases of antipsychotic-induced agranulocytosis.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalLupus
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Fcγ Receptor
  • olanzapine
  • polymorphisms
  • psychosis
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Fingerprint Dive into the research topics of 'Olanzapine-induced neutropenia in a patient with systemiclupus erythematosus: A role of FcγRIIIb polymorphism?'. Together they form a unique fingerprint.

  • Cite this

    Salviati, M., Ortona, E., Colasanti, T., Francia, A., Pontecorvo, S., & Delle Chiaie, R. (2012). Olanzapine-induced neutropenia in a patient with systemiclupus erythematosus: A role of FcγRIIIb polymorphism? Lupus, 21(1), 97-99. https://doi.org/10.1177/0961203311415889